Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction - Neuroscience and Medicine

NM > Vol.3 No.4, December 2012

Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction ()

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Download as PDF (Size: 713KB) PP. 387-393

DOI: 10.4236/nm.2012.34048 4,936 Downloads 6,930 Views Citations

Author(s)

Wei-Min Xiong, Jia-Hui Huang, Lei Xie, Yuan Qiao, Xin-Min Lu, Jiang-Chen Peng, Jin-Jia Hu

Affiliation(s)

Department of Gastroenterology, Shanghai 445 Hospital, Shanghai, China.
Medical College of Shanghai Jiao Tong University, Shanghai, China..

ABSTRACT

Nerve injury commonly contributes to irreversible functional impairment, reconstruction of the function of muscle is big challenge. In denervated skeletal muscle, therapid expression of MyoD mRNA and protein also occurs during early postdenervation, which suggested that the function of denervation-induced MyoD may be to prevent denervation-induced skeletal muscle atrophy. However, the detail mechanism is not clear. Therefore, in this study, we established a stable-transfected MyoD L6 cell line. After the operation for cutting the rats’ tibial nerve, the MyoD-L6 cells were injected in the gastrocnemius, the function of the gastronemius was monitored. It was found that injected the MyoD-L6 cells could attenuate the muscle atrophy and dysfunction. Therefore, overexpression of MyoD could serve as a new therapy strategy to cure denervation-induced dysfunction of skeletal muscle.

KEYWORDS

MyoD; Denervation; Rat Skeletal Muscle; Atrophy; Dysfunction

Share and Cite:

W. Xiong, J. Huang, L. Xie, Y. Qiao, X. Lu, J. Peng and J. Hu, "Overexpression of MyoD Attenuates Denervated Rat Skeletal Muscle Atrophy and Dysfunction," Neuroscience and Medicine, Vol. 3 No. 4, 2012, pp. 387-393. doi: 10.4236/nm.2012.34048.

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