Author(s)

Shinichi Antoku, Hiroyuki Ito, Mizuo Mifune, Hiroko Nawata, Masahiro Kato

Department of Diabetes, Metabolism and Kidney Disease, Edogawa Hospital, Tokyo, Japan.
Department of Internal Medicine, Edogawa Hospital, Tokyo, Japan.
Department of Neurology, Edogawa Hospital, Tokyo, Japan.

Tubulointerstitial nephritis complicated by primary Sj?gren’s syndrome in a patient under treatment for type 2 diabetes mellitus was diagnosed in the early stage of the disease by renal biopsy. The symptoms of primary Sj?gren’s syndrome, such as thirst and polydipsia, were masked by the characteristic symptoms of type 2 diabetes mellitus. An association between sicca symptoms and diabetes mellitus (types 1 and 2) has been previously reported. Hence, it is possible that there are common underlying immunological mechanisms between primary Sj?gren’s syndrome and diabetes mellitus of both types. Intervention with steroids in a timely manner appears to have prevented or slowed the progression of re- nal impairment.

Tubulointerstitial Nephritis; Sjögren’s Syndrome; Type 2 Diabetes Mellitus

S. Antoku, H. Ito, M. Mifune, H. Nawata and M. Kato, "Tubulointerstitial Nephritis Complicated with Primary Sjögren’s Syndrome under Treatment for Type 2 Diabetes Mellitus," Open Journal of Nephrology, Vol. 2 No. 4, 2012, pp. 105-108. doi: 10.4236/ojneph.2012.24017.