Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens - Journal of Agricultural Chemistry and Environment

JACEN > Vol.1 No.1, November 2012

Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens ()

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DOI: 10.4236/jacen.2012.11005 5,889 Downloads 13,673 Views Citations

Author(s)

Dong Gu Lee, So-Youn Mok, Changsun Choi, Eun Ju Cho, Hyun Young Kim, Sanghyun Lee

Affiliation(s)

Department of Food and Nutrition, Chung-Ang University, Anseong, South Korea.
Department of Food Science and Nutrition, Pusan National University, Busan, South Korea.
Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, South Korea.
Department of Integrative Plant Science, Chung-Ang University, Anseong, South Korea.

ABSTRACT

To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC₅₀ value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC₅₀ value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.

KEYWORDS

Blumea balsamifera; Apigenin; Aldose Reductase Inhibition; HPLC

Share and Cite:

D. Lee, S. Mok, C. Choi, E. Cho, H. Kim and S. Lee, "Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens," Journal of Agricultural Chemistry and Environment, Vol. 1 No. 1, 2012, pp. 28-33. doi: 10.4236/jacen.2012.11005.

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