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Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens

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DOI: 10.4236/jacen.2012.11005    4,955 Downloads   11,877 Views Citations

ABSTRACT

To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.


Cite this paper

D. Lee, S. Mok, C. Choi, E. Cho, H. Kim and S. Lee, "Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens," Journal of Agricultural Chemistry and Environment, Vol. 1 No. 1, 2012, pp. 28-33. doi: 10.4236/jacen.2012.11005.

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