Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone

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DOI: 10.4236/ojpathology.2012.24029    3,185 Downloads   5,376 Views  Citations

ABSTRACT

We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed with IgG-λ-type multiple myeloma and treated with melphalan and prednisolone plus bortezomib, achieving a complete remission. Four months later, his left scrotum began to swell and pathological investigation of a needle biopsy specimen revealed proliferation of plasma cells expressing IgG-λ, confirming myeloma recurrence. However, bone marrow aspiration samples showed no significant increase in myeloma cells and there was no skewed deviation of the K/λ ratio on flow-cytometric analysis. The extramedullary tumors disappeared completely soon after treatment with lenalidomide plus dexamethasone, and the patient was judged to be in very good partial remission based on negative M-protein results by serum immunoelectrophoresis. This is the first report, to our knowledge, describing complete disappearance of a testicular plasmacytoma after treatment with lenalidomide as the key-drug.

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M. Hagihara, M. Inoue, J. Hua, N. Iwaki, K. Yoshioka and T. Kobayashi, "Rapid Disappearance of Testicular Plasmacytoma after Treatment with Lenalidomide plus Dexamethasone," Open Journal of Pathology, Vol. 2 No. 4, 2012, pp. 155-158. doi: 10.4236/ojpathology.2012.24029.

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