Author(s)

Merve Olukman, Oya Şanlı, Ebru Kondolot Solak

Department of Chemistry and Chemical Processing Technology, Atatürk Vocational High School, Gazi University, Ankara, Turkey.
Department of Chemistry, Faculty of Science, Gazi University, Ankara, Turkey.

In this research; the release of 5-Fluorouracil (5-FU) from different ionically crosslinked alginate (Alg) beads was investigated by using Fe³⁺, Al³⁺, Zn²⁺, and Ca²⁺, ions as crosslinking agent. The prepared beads were characterized by Fourier Transform Infrared Spectroscopy (FTIR) Differential Scanning Calorimetry (DSC) and Scanning Electron Micros-copy (SEM). The drug release studies were carried out at three pH values 1.2, 6.8 and 7.4 respectively each for two hours. The effects of the preparation conditions as crosslinker type, drug/polymer (w/w) ratio, crosslinker concentration and time of exposure to crosslinker on the release of 5-FU were investigated for 6 hours at 37℃. It was observed that 5-FU release from the beads followed the order of Fe > Zn > Al > Ca-Alg and increased with increasing drug/polymer ratio. At the end of 6 hours, the highest 5-FU release was found to be 90% (w/w) for Fe-Alg beads at the drug/polymer ratio of 1/8 (w/w), crosslinker concentration of 0.05 M, exposure time of 10 minutes respectively. The swelling measurements of the beads supported the release results. Release kinetics was described by Fickian and non-Fickian approaches.

Anticancer Drug; pH Responsive Release; Alginate; Ionically Crosslinking; Controlled Release; 5-Fluorouracil

M. Olukman, O. Şanlı and E. Solak, "Release of Anticancer Drug 5-Fluorouracil from Different Ionically Crosslinked Alginate Beads," Journal of Biomaterials and Nanobiotechnology, Vol. 3 No. 4, 2012, pp. 469-479. doi: 10.4236/jbnb.2012.34048.