Author(s)

Saeed Balalaie, Shahrzad Abdolmohammadi, Bita Soleimanifard

Department of Chemistry, East Tehran Branch (Qiamdasht), Islamic Azad University, Tehran, Iran.
Peptide Chemistry Research Center, K.N. Toosi University of Technology, Tehran, Iran.

A simple and fastthree-component synthesis of new and biologically active hexahydro-2-quinolinecarboxylic acid scaf-fold 4 was carried out using cyclocondensation reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 under solvent-free conditions and at room temperature. This protocol has the advantages of facility, easy work-up, high yields, short reaction time and environmentally friendly character.

Arylmethylidene Pyruvic Acid; Hexahydro-2-quinolinecarboxylic Acids; Solvent-Free Conditions; One-Pot Three-Component Reaction

S. Balalaie, S. Abdolmohammadi and B. Soleimanifard, "Facile One-Pot Synthesis of Novel Hexahydro-2-quinolinecarboxylic Acids under Solvent-Free Reaction Conditions," International Journal of Organic Chemistry, Vol. 2 No. 3, 2012, pp. 276-281. doi: 10.4236/ijoc.2012.23037.