Author(s)

Supriti Sen, Sandipan Sarkar, Pijush Kundu, Subrata Laskar

Department of Chemistry, The University of Burdwan, Golapbag, India.

A newly designed quinazoline based compound, 6-pyridin-2-yl-5,6-dihydro-benzo[4,5]imidazo[1,2-c] quinazoline (PDBIQ) has shown the ability for the easy detection of nineteen amino acids on thin-layer chromatography plates as a spray reagent. This new reagent enabled to produce various distinguishable colors with amino acids with different R_F values. The detection limits and the binding ability of PDBIQ with amino acids have been calculated. PDBIQ is also able to detect aminoacids from hydrolised seed protein. The title compound also exhibited profound inhibitory action against some gm (+ve) and gm (-ve) bacterial organisms. This paper deals with synthesis, spectroscopic application and biological evaluation of the organic moity.

Thin-Layer Chromatography; Amino Acid; Ninhydrin; Binding Constant; Antimicrobial Property

S. Sen, S. Sarkar, P. Kundu and S. Laskar, "Separation of Amino Acids Based on Thin-Layer Chromatography by a Novel Quinazoline Based Anti-Microbial Agent," American Journal of Analytical Chemistry, Vol. 3 No. 9, 2012, pp. 669-674. doi: 10.4236/ajac.2012.39088.