Author(s)

Temitayo Olufunmilayo Aiyelabola, Isaac Ayoola Ojo, Adeleke Clement Adebajo, Grace Olufunmilayo Ogunlusi, Olayinka Oyetunji, Ezekiel Olugbenga Akinkunmi, Adebowale Olusoji Adeoye

Adis Pharma Inc., 5238 Palmetto Place, Mississauga, ON L5M OC8, Canada.
Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife, Nigeria.
Department of Chemistry, University of Botswana, Gaborone, Botswana.
Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

Metal(II) coordination compounds of glycine and ph-enylalanine were synthesized and characterized using infrared and electronic spectroscopic, and magnetic susceptibility measurements. The complexes were tested for antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Methicillin Resistant Staphy-lococcus aureus (MRSA), Escherichia coli, Pseudo-monas aeruginosa, Proteus vulgaris and Candida albicans. The stoichiometric reaction between the metal (II) ions and ligands in molar ratio M:L (1:3) [where M = Mn, Co, Ni, Cu and Cd; L= glycine; phenylalanine] resulted in the formation of five-coordinate square pyramidal dinuclear geometry for both copper complexes and six-coordinate octa-hedral geometry for the other complexes. The spectroscopic and magnetic moment data suggested that the ligands coordinated via both their amino and carboxylate ion moieties. The complexes demonstrated better activities against one or more of the tested microbes than acriflavine, the standard drug used.

Glycine; Phenylalanine; Coordination Compound; Antimicrobial; Chelation

Aiyelabola, T. , Ojo, I. , Adebajo, A. , Ogunlusi, G. , Oyetunji, O. , Akinkunmi, E. and Adeoye, A. (2012) Synthesis, characterization and antimicrobial activities of some metal(II) amino acids’ complexes. Advances in Biological Chemistry, 2, 268-273. doi: 10.4236/abc.2012.23034.