Author(s)

Lilliana Ciotta, Isabella Pagano, Vito Leanza, Mariagrazia Stracquadanio, Carlo Pafumi

Institute of Obstetric and Gynecological pathology – University of Catania.

Premature Ovarian Failure (POF) is a heterogeneous syndrome characterized by Hypergonadotropic Hypogonadism that affects about 1% of women younger than 40 years old, while an incidence of 1/1000 is reported in women younger than 30 years old. [1] This hormonal disorder is caused by the loss of the ovarian response towards the pituitary gonadrotropins synthesis (FSH and LH) that are secreted according to the inhibitory feedback between hypothalamus, pituitary gland and gonads.

Premature Ovarian Failure; Hypergonadotropic Hypogonadism; Inhibitory Feedback

Ciotta, L. , Pagano, I. , Leanza, V. , Stracquadanio, M. and Pafumi, C. (2012) Genetics pathogenesis in the ovarian insufficiency. Open Journal of Preventive Medicine, 2, 344-349. doi: 10.4236/ojpm.2012.23050.