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Development and validation of HPTLC method for niacin and simvastatin in binary combination

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DOI: 10.4236/abb.2010.12018    5,544 Downloads   13,722 Views Citations

ABSTRACT

A simple, sensitive and validated HPTLC method has been developed to determine Niacin and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a RP18 plate using a mixture of Methanol: Water: Acetic acid (60:40:0.1) at a wavelength of 237 nm. Linearity of themethod was found to be in the concentration range of 5000.0-25000.0 μg/ml for niacin and 100.0-500.0 μg/ml for simvastatin with correlation coefficient greater than 0.999. The method can be used for simultaneous determination of Niacin and Simvastatin.

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Tiwari, P. and Sathe, P. (2010) Development and validation of HPTLC method for niacin and simvastatin in binary combination. Advances in Bioscience and Biotechnology, 1, 131-135. doi: 10.4236/abb.2010.12018.

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