Author(s)

Harshadas Mitaram Meshram, Vikas Madhukar Bangade, Bandi Chennakesava Reddy, Gudimella Santosh Kumar, Pramod Bhagwan Thakur

Discovery Laboratory, Organic Chemistry Division—I, Indian Institute of Chemical Technology, Hyderabad, India.

The synthesis of C-substituted and N-substituted pyrrole is described by the reaction of phenacyl bromides, pentane-2, 4-dione and amine in aqueous medium using DABCO as a catalyst. The method is very convenient and applicable for alkyl as well as aryl amines and phenacyl bromides. The procedure is amenable for the synthesis of new substituted pyrroles. Moreover, aqueous medium makes the method more eco-friendly.

Phenacyl Bromide; Pentane-2, 4-dione; Amines; DABCO; Water; Pyrroles

H. Meshram, V. Bangade, B. Reddy, G. Kumar and P. Thakur, "DABCO Promoted an Efficient and Convenient Synthesis of Pyrrole in Aqueous Medium," International Journal of Organic Chemistry, Vol. 2 No. 2, 2012, pp. 159-165. doi: 10.4236/ijoc.2012.22024.