Author(s)

Ramaseri Sunder Sharada, Hanumanth Surekha Rani, Satya Sudheer Pydi, Jonnalagada Subbanna, Vijaya lakshmi Valluri

1Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health & Research Centre, Hyderabad, India.
Department of Genetics, Osmania University, Hyderabad, India.
Immunology and Molecular Biology Division, LEPRA India-Blue Peter Public Health & Research Centre, Hyderabad, India.

CD38 expression on CD8+ cells seems to correlate well with HIV viral-loads, while the ex-pression levels are thought to be low in patients with tuberculosis. This study aimed at determining the levels of CD38 expression in HIV+ individuals who develop tuberculosis. Expression levels of CD8 and CD38 were analysed in peripheral blood collected from HIV (73), TB (32), HIV-TB (31) and healthy controls (20). The percentage of CD8+/CD38+ cells significantly increased during the first few years of seropositivity and decreased during 5 - 6 years. A decline in the expression of CD38, especially on CD8+ cells in a HIV+ individual within first 2 years of seropositivity, may be indicative of susceptibility to tuberculosis. This observation was reiterated when two patients developed TB during follow-up. CD38 on CD8 cells could perhaps be useful as an early biomarker for tuberculosis in HIV-positive individuals.

HIV-TB; CD38; CD8; CD4; Viral Load

Sharada, R. , Rani, H. , Pydi, S. , Subbanna, J. and Valluri, V. (2012) CD38 expression on CD8+ cells—Its influence on development of tuberculosis in HIV positive individuals. Open Journal of Immunology, 2, 65-71. doi: 10.4236/oji.2012.22008.