Author(s)

Gaoyan Deng, Fenghua Wang, Junjie Sun, Jiacong Mo, Zhijian Deng, Wei Liu

Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou, China.
Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Aims: to evaluate the Expression of NSE and AFI before and after relieving ureteral obstruction in fatal lamb’s lungs with unilateral hydronephrosis. Study Design and Subjects: Forty-five pregnant lambs were randomly divided into 3 groups. Eighteen lambs were in the hydronephrotic model group. The second group included 9 lambs in which ureteral obstruction was relieved 3 weeks after the initial operation. Eighteen lambs were in the control group which was just performed open hysterotomies. Outcome measures: The amniotic fluid index (AFI) and the expression of neuronspecific enolase (NSE) in the lungs were tested. Results: In the hydronephrotic model group, the AFI was less and the expression of NSE was greater than the control group. The AFI and expression of NSE were similar to the control group after relieving the ureteral obstruction. Conclusions: The AFI and expression of NSE return to normal after after relieving the ureteral obstruction, which meant that relieving ureteral obstruction is perhaps beneficial to lung development.

Hydronephrosis; Neuron Specific Enolase; Fetus; Lamb

G. Deng, F. Wang, J. Sun, J. Mo, Z. Deng and W. Liu, "Expression of NSE and AFI in Fatal Lamb’s Lungs before and after Relieving Ureteral Obstruction," Surgical Science, Vol. 3 No. 6, 2012, pp. 318-321. doi: 10.4236/ss.2012.36063.