Author(s)

Menghua Luo, Anne C. Voss, Vikkie A. Mustad, Lyudmila Ivanova, Tatiana Morugova, Elena Alexeeva, Lyudmila Ruyatkina, Lyudmila Suplotova

Abbott Nutrition, Columbus, USA.
Bashkir State Medical University Based on City Clinical Hospital #21, Ufa, Russia.
Kuban State Medical University Based on City Clinical Hospital of Emergency Care, Krasnodar, Russia.
Novosibirsk State Medical University Based on City Clinical Hospital #1, Novosibirsk, Russia.
Russian State Medical University of Federal Agency of Healthcare and Social Development Based on City Clinical Hospital #68, Moscow, Russia.
Tyumen State Medical Academy, Tyumen, Russia.

Background: Postprandial hyperglycemia is an independent risk factor for diabetes-associated complications in individuals with type 2 diabetes. Dietary modification plays an important role in glycemic control. This study was to examine the efficacy of a diabetes specific formula (DSF) during a 4-hour postprandial meal tolerance test (MTT) in Russian subjects with type 2 diabetes receiving oral hypoglycemic medication. Methods: In a randomized, cross-over design, 168 eligible subjects from 11 study centers consumed, in a random order, the DSF (230 mL) or a common light hospital breakfast (i.e. standard meal) on two different occasions. The amounts of macronutrients were similar between the two meals providing ~200 kcal, 11 g protein, 26 g carbohydrate and 8 g fat. Capillary glucose levels were measured at baseline (before meal consumption), and post-meal consumption at 30, 60, 90, 120, 180 and 240 min. Results: The DSF was well tolerated in all subjects. There were 111 subjects completed the study per protocol (mean ± SEM: age: 58.6 ± 0.8 yr, BMI: 31.8 ± 0.42 kg/m2, waist circumference: 101 ± 1.3 cm, HbA1c: 8.0% ± 0.1%). Glucose levels reached peak values at 60 min (median) and the lowest levels at the end of the 240-min MTT test. The mean positive area under the curve (PAUC), the primary outcome, was significantly smaller after DSF consumption (mean ± SEM: 183.02 ± 18.74, median: 132.55) than the PAUC after consumption of the standard meal (mean ± SEM: 239.95 ± 23.11, median: 166.89; p = 0.027). The actual and adjusted peak glucose concentrations were similar between the two treatments. Conclusions: In patients with type 2 diabetes receiving oral hypoglycemic agents, compared to a hospital meal, the DSF improves postprandial glucose control. Combining results from earlier studies, long-term use of DSF may be beneficial to improve glucose management and decrease diabetes-associated complications.

Type 2 Diabetes; Diabetes Specific Formula; Glucose Control

Luo, M. , C. Voss, A. , A. Mustad, V. , Ivanova, L. , Morugova, T. , Alexeeva, E. , Ruyatkina, L. and Suplotova, L. (2012) Four-hour evaluation of a medical food in subjects with type 2 diabetes receiving oral hypoglycemic medication. Journal of Diabetes Mellitus, 2, 214-220. doi: 10.4236/jdm.2012.22034.