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Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease

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DOI: 10.4236/ajmb.2012.22012    3,427 Downloads   7,159 Views

ABSTRACT

Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.

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Scanu, A. , Stafforini, D. and Edelstein, C. (2012) Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease. American Journal of Molecular Biology, 2, 110-112. doi: 10.4236/ajmb.2012.22012.

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