Author(s)

B. Karthikeyan, V. Srinivasan

Department of Chemistry;Annamalai university, Annamalainagar, India.

ABSTRACT A simple, economic, and time-efficient related substance, GC method has been developed for the analysis of 1,4-Cyclohexanedione mono- ethylene ketal(will be specified as ketal) in the presence of a potential impurity 1,4-cyclohexa- nedione bis (ethylene ketal) [will be specified as diketal]. Successful chromatographic separa- tion of the ketal from the impurity was achieved on a DBWAX ETR, 30 m x 0.32 mm x 1.0μ FT column with nitrogen as carrier gas and FID detector. The method was validated for linearity, accuracy, precision, and specificity and can be used for quality control during manufacture of ketal. A validated GC method is reported for the ketal for the first time.

Column Gas Chromatography; 1, 4-Cyclohexanedione Mono-Ethylene Ketal; 1, 4-Cyclohexanedione Bis (Ethylene Ketal); Validation

Karthikeyan, B. and Srinivasan, V. (2010) A validated, related substance, GC method for 1,4-cyclohexanedione mono-ethylene Ketal. Journal of Biophysical Chemistry, 1, 72-75. doi: 10.4236/jbpc.2010.11009.