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Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy

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DOI: 10.4236/jbise.2012.53013    3,144 Downloads   5,581 Views Citations


In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.

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Novelli, G. , Morabito, V. , Ferretti, G. , Novelli, S. , Ruberto, F. , Pernice, M. , Cristina Donfrancesco, C. and Panici, P. (2012) Polymixin-B hemoperfusion in a case intolerant to conventional antibiotic therapy. Journal of Biomedical Science and Engineering, 5, 101-103. doi: 10.4236/jbise.2012.53013.

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