Author(s)

Har Lal Singh, Jangbhadur Singh

Department of Chemistry, Faculty of Engineering & Technology, Mody Institute of Technology and Science, Sikar, India;.

New dibutyltin(IV) complexes of Schiff base derived from 5-chloroindoline-2,3-dione, indoline- 2,3-dione with amino acids (tryptophan, alanine and valine) were synthesized and characterized by elemental analysis, IR, electronic spectra, conductance measurements, and biological activity. The analytical data showed that the Schiff base ligand acts as bidentate towards metal ions via the azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of M:L (1:2) to form metal complexes. NMR (¹H, ¹³C and ¹¹⁹Sn) spectral data of the ligands and metal complex agree with proposed structures. The conductivity values between 14 - 27 ohm^-1cm²mol^-1 in DMF imply the presence of non-electrolyte species. 3D molecular modeling and analysis of bond lengths and bond angles have also been conducted for a representative compound, [Bu₂Sn(L²)₂], to substantiate the proposed structures. Antibacterial results indicate that the metal complexes are more active than the free ligands.

Schiff Base; Isatins; Amino Acids; Dibutyltin (IV) Complexes; Spectral Studies; Antimicrobial Activity

Singh, H. and Singh, J. (2012) Synthesis, spectral, 3D molecular modeling and antibacterial studies of dibutyltin (IV) Schiff base complexes derived from substituted isatin and amino acids. Natural Science, 4, 170-178. doi: 10.4236/ns.2012.43025.