Author(s)

Marjolein W. J. Kuiper, Ellen J. van der Gaag

Department of Pediatrics, Ziekenhuisgroep Twente, Hengelo, The Netherlands..

Background: There is no effective treatment for children with subclinical hypothyroidism. The natural course of subclinical hypothyroidism shows a normalization rate of 41% for Thyroid Stimulating Hormone (TSH). Objective; The thyroid needs (among others) iron, iodine, and vitamin A for a proper thyroid hormone synthesis. We hypothesize that with a dietary change, more children can normalize their TSH. Design: In this case-control study, 54 children aged 1 - 14 years with subclinical hypothyroidism were divided into a diet group and a control group. The diet consisted of green vegetables, beef, full fat milk, and butter. The diet was followed for at least 3 months. A total of 27 patients comprised the diet group and 27 the control group. TSH, Free T4 (FT4), and Body Mass Index (BMI) were evaluated during the follow up. Results: By following this diet, TSH levels decreased significantly compared to when following the natural course. FT4 levels did not change during the follow up. The diet group realized a change of normalizing their TSH with a RR 2.8 (95% CI 1.45 - 5.61). There were no changes in BMI after following the diet. Conclusions: Even though our study population was small, we observed the association of a dietary change and normalization of TSH in children with subclinical hypothyroidism, without adverse effects.

Subclinical Hypothyroidism; TSH, BMI; Vitamin A; Dairy Products; Beef; Vegetables

M. Kuiper and E. Gaag, "Subclinical Hypothyroidism in Children Can Normalize after Changes in Dietary Intake," Food and Nutrition Sciences, Vol. 3 No. 3, 2012, pp. 411-416. doi: 10.4236/fns.2012.33059.