Author(s)

Kamatala Chinna Rajanna, Mukka Satish Kumar, Purugula Venkanna, Soma Ramgopal, Marri Venkateswarlu

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Nitration of aromatic Compounds is triggered by Vilsmeier-Haack reagent (DMF/POCl3) or (DMF/SOCl2) in the presence of KNO3 or NaNO2 under conventional and non-conventional conditions. The reactions af- forded corresponding Nitro derivatives in very good yield with high regioselectivity. The results obtained in non-conventional methods (Micro wave irradiation, Grinding, Sonication) are comparable with those ob- tained under conventional conditions, but the reaction times of former conditions are substantially shorter than that of the latter.

Nitration, KNO3 or NaNO2, Vilsmeier-Haack Reagent, Microwave Irradiation (MWI), Grinding, Sonication

K. Rajanna, M. Kumar, P. Venkanna, S. Ramgopal and M. Venkateswarlu, "Vilsmeier Haack Adducts as Effective Reagents for Regioselective Nitration of Aromatic Compounds under Conventional and Non-Conventional Conditions," International Journal of Organic Chemistry, Vol. 1 No. 4, 2011, pp. 250-256. doi: 10.4236/ijoc.2011.14036.