Author(s)

Marri Venkateswarlu, Kamatala Chinna Rajanna, Mukka Satish Kumar, Utkoor Umesh Kumar, Soma Ramgopal, Pondichery Kuppuswamy Saiprakash

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Acetylation and benzoylation reactions of certain aromatic aldehydes, ketones with Vilsmeier-Haack Re- agents using Acetamide and Oxychloride (SOCl2 or POCl3) under conventional (thermal) and non conven- tional [microwave irradiated (MIR), ultrasonic assisted and solvent free mortar pestle (grinding)] conditions. Reactions afforded good to excellent yields of products with both the VH reagents, reaction times were fairly less in the case of [amide/POCl3] than those of [amide/SOCl2] reagent. Reactions are dramatically acceler- ated in under sonicated and microwave irradiations with a trend: MIR (few seconds) >> Sonication (minutes) > Grinding (min) >> thermal (several hrs).

Acetylation, Benzoylation, Vilsmeier-Haack Reagent (VHR), Acetamide, Benzamide, Micro Wave Irradiation, Grinding, Sonication

M. Venkateswarlu, K. Rajanna, M. Kumar, U. Kumar, S. Ramgopal and P. Saiprakash, "Rate Enhancements in the Acetylation and Benzoylation of Certain Aromatic Compounds with Vilsmeier-Haack Reagents Using Acetamide, Benzamide and Oxychlorides under Non-Conventional Conditions," International Journal of Organic Chemistry, Vol. 1 No. 4, 2011, pp. 233-241. doi: 10.4236/ijoc.2011.14034.