Author(s)

Lifeng Yan, Tao Wei

Hefei National Laboratory for Physical Science at Microscale, and Department of Chemical Physics, University of Science and Technology of China, Hefei, 230026, P.R.Chin.

In homogeneous media, N,N-Dimethylacrylamide (DMA) was grafted copolymerization to cellulose by a metal-catalyzed atom transfer radical polymerization (ATRP) process. First, cellulose was dissolved in DMAc/LiCl system, and it reacted with 2-bromoisobutyloyl bromide (BiBBr) to produce macroinitiator (cell-BiB). Then DMA was polymerized to the cellulose backbone in a homogeneous DMSO solution in presence of the cell-BiB. Characterization with FT-IR, NMR, and GPC measurements showed that there obtained a graft copolymer with cellulose backbone and PDMA side chains (cell-PDMA) in well-defined structure. The proteins adsorption studies showed that the cellulose membranes modified by the as-prepared cell-PDMA copolymer owns good protein adsorption resistancet.

cellulose, atom transfer radical polymerization (ATRP), homogeneous, graft copolymerization, hemocompatibility.

Yan, L. and Wei, T. (2008) Graft Copolymerization of N,N-Dimethylacrylamide to Cellulose in Homogeneous Media Using Atom Transfer Radical Polymerization for Hemocompatibility. Journal of Biomedical Science and Engineering, 1, 37-43. doi: 10.4236/jbise.2008.11006.