Prof. Hiroyuki
Shibata
Akita University, Japan
Email: hiroyuki@med.akita-u.ac.jp
Qualifications
1991 Ph.D., Tohoku University,
Japan
1987 M.D., Tohoku University, Japan
1987 B.Sc., Tohoku
University, Japan
Publications (selected)
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Lin L, Liu Y, Li H, Li P-K, Shibata H, Iwabuchi Y, Lin J. (2011) Targeting colon cancer stem cells
using a new curcumin analogue, GO-Y030. Br
J Cancer, 105, 212
– 220.
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Yoshioka T, Kato S, Gamoh M, Chiba N, Suzuki T, Sakayori N,
Kato S, Shibata H, Shimodaira H, Otsuka K, Kakudo Y, Takahashi S, Ishioka C
(2009) Phase I/II study of
sequential therapy with irinotecan and S-1 for metastatic colorectal cancer. Br J Cancer, 101, 1972-1977.
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Shibata H, Takano H, Ito M, Shioya H, Hirota M, Matsumoto
H, Kakudo Y, Ishioka C, Akiyama T, Kanegae Y, Saito I, Noda T (2007) a-Catenin is essential in intestinal
adenoma formation. Proc
Natl Acad Sci U S A., 104, 18199-18204.
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Ohori, H., Yamakoshi, H., Tomizawa,
M., Shibuya, M., Kakudo, Y., Takahashi, A., Takahashi, S., Kato, S., Suzuki,
T., Ishioka, C., Iwabuchi, Y., Shibata, H.(2006) Synthesis and biological
analysis of new curcumin analogues bearing an enhanced potential for the
medicinal treatment of cancer. Mol Cancer Ther, 5, 2563-2571
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Kakudo Y, Shibata H, Otsuka K, Kato S, Ishioka C. (2005) Lack of
correlation between p53-dependent transcriptional activity and the ability to
induce apoptosis among 179 mutant p53s. Cancer Res. 65, 2108-2114.
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Kato S, Han SY, Liu W, Otsuka K, Shibata H, Kanamaru R, Ishioka C.
(2003) Understanding the
function-structure and function-mutation relationships of p53 tumor suppressor
protein by high-resolution missense mutation analysis. Proc Natl Acad Sci U S
A. 100, 8424-8429.
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Gallagher RC, Hay T, Meniel V, Naughton C, Anderson TJ, Shibata H,
Ito M, Clevers H, Noda T, Sansom OJ, Mason JO, Clarke AR. (2002) Inactivation
of Apc perturbs mammary development, but only directly results in acanthoma in
the context of Tcf-1 deficiency. Oncogene. 21, 6446-6457.
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Hasegawa S, Sato T, Akazawa H, Okada
H, Maeno A, Ito M, Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y,
Yamamura Ki K, Katamine S, Noda T. (2002) Apoptosis in neural crest cells by
functional loss of APC tumor suppressor gene. Proc Natl Acad Sci U S A. 99,
297-302.
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Han SY, Kato H, Kato S, Suzuki T,
Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C. (2000)
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide
phosphatase assay. Cancer Res. 60, 3147-3151.
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Shimodaira H, Filosi N,
Shibata H, Suzuki T, Radice P, Kanamaru R, Friend SH, Kolodner RD, Ishioka C.
(1998) Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae.
Nature Genet. 19, 384-389.
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Shibata H, Toyama K, Shioya H, Ito M,
Hirota M, Hasegawa S, Matsumoto H, Takano H, Akiyama T, Toyoshima K, Kanamaru
R, Kanegae Y, Saito I, Nakamura Y, Shiba K, Noda T. (1997) Rapid colorectal
adenoma formation initiated by conditional targeting of the Apc gene. Science.
3, 278, 120-123.
Profile Details
http//www.med.akita-u.ac.jp/~medonco/