Guangdi Chen

Center for Hearing & Deafness, SUNY at Buffalo, USA

Associate research professor



1989 Ph.D., Shanghai Institute of Physiology, Chinese Academy of Science, Auditory Neuroscience

1985 M.S., Shanghai Institute of Physiology, Chinese Academy of Science, Auditory Physiology

1982 B.S., Nanjing Normal University, Biology

Publications (selected)

  1. Chen, G.D., 2013. The relationship between hearing loss and auditory hair cell loss in rats. Canadian Hearing Report. 8(1): 39-40.
  2. Bielefeld, E.C., Tanaka, C., Chen, G.D., Coling, D., Li, M.N., Henderson, D., Fetoni, A.R., 2013. A Src-PTK inhibitor to reduce cisplatin ototoxicity while preserving its anti-tumor effect. Anti-Cancer Drugs. 24(1), 43-51.
  3. Chen, G.D., Stolzberg, D., Lobarinas, E., Sun, W., Ding, D., Salvi, R., 2013. Review: Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus. Hear. Res. 295: 100-113.
  4. Chen, G.D., Manohar, S., Salvi, R., 2012. Amygdala hyperactivity and tonotopic shift after salicylate exposure. Brain Res. 1485: 63-76.
  5. Tanaka, C., Coling, D., Manohar, S., Chen, G.D., Hu, B.H., Salvi, R., Henderson, D., 2012. Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea. Neurobiology of Aging. 33: 1842.e1-1842.e14.
  6. Yang, W., Hu, B., Chen, G.D., Bielefeld, E.C., Henderson, D., 2011. L-NAC protect hair cells in the rat cochlea from injury of exposure to styrene. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 25(4):176-179.
  7. Chen, G.D., Henderson, D., 2011. Ototoxicity of styrene. Journal of Otology, 6(2): 1-9.
  8. Chen, G.D., Lobarinas, E., Ding, D., Salvi, R., 2011. Hearing loss: what's in the pipeline. Drugs of the Future. 36 (3): 209-227.
  9. Stolzberg, D., Chen, G.D., Allman, B., Salvi, R., 2011. Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex. Neurosci. 180, 157-164.
  10. Salvi, R., Lobarinas, E., Chen, G.D., Stolzberg, D., Ding, D., 2011. Animal Models of Hearing Loss and Tinnitus. CRC Handbook, Chapter 18, 419-453.
  11. Allman, B.L., Sun, W., Kraus, K.S., Ding, D., Chen, G.D., Stolzberg, D., Lobarinas, E., Salvi, R. 2010. Central auditory system neuroplasticity and hippocampal neurogenesis following ccohlear insults. In: Salami, A., (Ed.), Neuroplasticity in the auditory brainstem: from physiology to the drug therapy. Nova Science Publishers, Hauppauge, NY.
  12. Chen, G.D., Habiby Kermany, M., D’Elia, A., Ralli, M., Tanaka, C., Bielefeld, E.C., Ding, D., Henderson, D., Salvi, R., 2010. Too much of a good thing: Long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity. Hear. Res. 265, 63-69.
  13. Bielefeld, E.C., Tanaka, C., Chen, G.D., Henderson, D., 2010. Age-related hearing loss: Is it a preventable condition? Hear. Res. 264, 98-107.
  14. Tanaka, C., Bielefeld, E.C., Chen, G.D., Li, M.N., Henderson, D., 2009. Ameliorative Effects of an Augmented Acoustic Environment on Age-Related Hearing Loss in Middle-Aged Fischer 344/NHsd. Laryngoscope 119, 1374-1379.
  15. Kong, L., Chen, G.D., Zhou, X.H., McGinnis, J.F., Li, F., Cao, W., 2009. Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. Neurochem. Int. 54, 172-179.
  16. Chen, G.D., Henderson, D., 2009. Cochlear injuries induced by the combined exposure to noise and styrene. Hear. Res. 254, 25-33.
  17. Yang, W.P., Hu, B.H., Chen, G.D., Bielefeld, E.C., Henderson, D., 2009. Protective effect of N-acety-L-cysteine (L-NAC) against styrene-induced cochlear injuries. Acta Oto-Laryngologica. 129, 1036-1043.
  18. Tanaka, C., Chen, G.D., Hu, B.H., Chi, L.H., Li, M.N., Zheng, G.L., Bielefeld, E.C., Jamesdaniel, S., Coling, D., Henderson, D., 2009. The Effects of Acoustic Environment after Traumatic Noise Exposure on Hearing and Outer Hair Cells. Hear. Res. 250, 10-18.
  19. Chen, G.D., Li, M.N., Tanaka, C., Bielefeld, E., Hu, B.H., Habiby Kermany, M., Salvi, R., Henderson, D., 2009. Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: Function and morphology. Hear Res. 248, 39-47.
  20. Chen, G.D., 2008. Chapter 37: Noise. In: Information Resources in Toxicology, 4th edition. Eds by Philip Wexler, Steve Gilbert, Bert Hakkinen, Asish Mohapatra, Fred Stoss. Academic Press. Amsterdam, Boston, Heideiberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo. pp 323-327.
  21. Hu, B.H., Yang, W.P., Bielefeld, E.C., Li, M.N., Chen, G.D., Henderson, D., 2008. Apoptotic sensory cell death in the cochleae of aging Fischer 344 rats. Hear. Res. 245, 48-57.
  22. Chen, G.D., Tanaka, C., Henderson, D., 2008. Relationship between outer hair cell loss and hearing loss in rats exposed to styrene. Hear. Res. 243, 28-34.
  23. Bielefeld, E.C., Coling, D., Chen, G.D., Henderson, D., 2008. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. J. Negat. Results Biomed. 2008 Jul 11;7:4.
  24. Bielefeld, E.C., Coling, D., Chen, G.D., Li, M.N., Tanaka, C., Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33.
  25. Chen, G.D., Chi, L.H., Kostyniak, P.J., Henderson, D., 2007. Styrene induced alterations in biomarkers of exposure and effects in the cochlea: Mechanisms of hearing loss. Toxicol. Sci. 98(1), 167-177.
  26. Chen, G.D., Zhao, H.B., 2007. Effects of intense noise exposure on the outer hair cell plasma membrane fluidity. Hear. Res. 226, 14-21.
  27. Chen, G.D., 2006. Prestin gene expression in the rat cochlea following intense noise exposure. Hear. Res. 222, 54-61.
  28. Liu, Y., Yu, Y., Shaikh, J., Pouw, B, Daniels, A., Chen, G.D. and Matsumoto, R. R., 2005. Sigma receptors and drug abuse. In R. R. Matsumoto, W. D. Bowen, and T.-P. Su (Eds.), Sigma Receptors: Chemistry, Cell Biology, and Clinical Implications, Springer-Verlag.
  29. Liu, Y., Chen, G.D., Lerner, M.R., Brackett, D.J., Matsumoto, R.R., 2005. Cocaine up-regulates Fra-2 and receptor gene and protein expression in brain regions involved in addiction and reward. The Journal of Pharmacology and Experimental Therapeutics. 314, 770-779.
  30. Chen, G.D., Liu, Y., 2005. Mechanisms of noise-induced hearing loss potentiation by hypoxia. Hear. Res. 200, 1-9.
  31. Chen, G.D., Fechter, L.D., 2003. The relationship between noise-induced hearing loss and hair cell loss in rats. Hear. Res. 177(1-2), 81-90.
  32. Chen, G.D., 2002. Effect of hypoxia on noise-induced auditory impairment. Hear. Res. 172(1-2), 186-195.
  33. Sinex, D.G., Henderson, J., Li, H.Z., Chen, G.D., 2002. Responses of chinchilla inferior colliculus neurons to amplitude-modulated tones with different envelopes. JARO. 3(4), 390-402.
  34. Fechter, L.D., Chen, G.D., Johnson, D.L., 2002. Potentiation of noise induced hearing loss by low concentrations of hydrogen cyanide in rats. Toxicol. Sci. 66, 131-138.
  35. Fechter, L.D., Chen, G.D., Rao, D., 2002. Chemical asphyxiants and noise. Noise and Health. 4(14), 49-62.
  36. Fechter, L.D., Chen, G.D., Rao, D., 2001. Noise and occupational exposures. In: Noise Induced Hearing Loss: Basic Mechanisms, Prevention and Control. Eds by Henderson, D., Prasher, D., Kopke, R., Salvi, R., Hamernik, R. Noise Research Network Publications, London.
  37. Tawackoli, W., Chen, G.D. and Fechter, L.D., 2001. Disruption of cochlear potentials by chemical asphyxiants Cyanide and carbon monoxide. Neurotoxicol. and Teratol. 23, 157-165.
  38. Chen, G.D., Kong, J., Reinhard, K. and Fechter, L.D., 2001. NMDA-receptor blocker protects against permanent NIHL but not its potentiation by CO. Hear. Res. 154, 108-115.
  39. Fechter, L.D., Chen, G.D. and Rao, D., 2000. Characterizing conditions that favor potentiation of noise induced hearing loss by chemical asphyxiants. Noise and Health. 3(9), 11-21.
  40. Fechter, L.D., Chen, G.D. and Rao, D., Larabee, J., 2000. Predicting exposure conditions that facilitate the potentiation of noise-induced hearing loss by carbon monoxide. Toxicol. Sci. 58, 315-323.
  41. McWilliams, M.L., Chen, G.D. and Fechter, L.D., 2000. Low level toluene disrupts auditory function in guinea pigs. Toxicol. Appl. Pharmaco. 167, 18-29.
  42. McWilliams, M.L., Chen, G.D. and Fechter, L.D., 2000. Characterization of the ototoxicity of DFMO and its enantiomers. Toxicol. Sci. 56, 124-132.
  43. Fechter, L.D., Chen, G.D. and Prasher, D., 2000. Assessment of ototoxicity. The Ear. 3, 73-82.
  44. Chen, G.D., McWilliams, M. and Fechter, L.D., 2000. Succinate dehydrogenase (SDH) activity in hair cells: A correlate for permanent threshold elevations. Hear. Res. 145, 91-100.
  45. Sinex, D.G. and Chen, G.D., 2000. Neural responses to the onset of voicing are unrelated to other measures of temporal sensitivity. J.Acoust. Soc. AM. 107, 486-495.

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