Prof. Zhixiang Wang

Department of Cell Biology

Faculty of Medicine and Dentistry

University of Alberta, Canada


1989-1993  Ph.D., Biochemistry, Simon Fraser University, Canada
1982-1985  M.S., Zoology, Academia Sinica, China
1978-1982  B.S., Biology, Peking University, China


  1. Chen C., Uludag H.,Wang Z., Rezansoff A., Jiang H. (2011)inhibit migration, metabolic activity and osteogenic differentiation of human mesenchymal stem cells in vitro.Cells Tissues Organs (in press)
  2. Liu, L., Shi, H., Chen, X. andWang, Z.(2011) Regulation of EGF Receptor Endocytosis during Mitosis.Traffic12: 201-217.
  3. Pahara, J., Shi, H., Chen, X. andWang, Z.(2010)Dimerization Drives PDGF Receptor Endocytosis through a C-terminal Hydrophobic Motif Shared by EGF Receptor.Exp. Cell Res 15: 2237-50.
  4. Li, S, Wang, Q, Wang,Y. Chen, X. andWang, Z.(2009) PLC-γ1 and Rac1 co-regulates EGF-induced cytoskeleton remodelling and cell migration.Molecular Endocrinology23: 901-913.
  5. Pennock, S. andWang, Z. (2008) A Tale of Two Cbls:Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation.Mol. Cell. Biol.28: 3020-3037.
  6. Wang, Q.,Wu, F., andWang, Z.(2007)Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif1010LL1011as Essential in EGF Receptor Endocytosis.Exp. Cell Res.313: 3349-3363.
  7. Wang, Y., Wu, J. andWang, Z.(2006) Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor.Mol. Biol. Cell17: 2267-2277.
  8. Wang, Q., Villeneuve, G., andWang, Z.(2005) Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation.EMBO Rep.,6: 942-948.
  9. Wang, Y., Pennock, S., Chen, X.,Kazlauskas, A. andWang, Z.(2004) PDGF receptor-mediated signal transduction from endosomes.J. Biol. Chem.279: 8038-8046
  10. Wang, Y. andWang, Z.(2003) Regulation of EGF-induced phospholipaseC-1 translocation and activation by its SH2 and PH domains.Traffic4: 618-630
  11. Pennock, S. and Wang, Z. (2003)Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling.Mol. Cell. Biol.23: 5803-5815
  12. Wang Y, Pennock S, Chen X. andWang Z.. Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Sci. STKE 2002(161): PL17 .
  13. Wang, Y., Pennock, S, Chen, X. andWang, Z.(2002) Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival.Mol. Cell. Biol.22 (20): 7279-7290 [Cover illustration onMCB22 (22)].Science's STKEhighlighted this paper in "This Week in Signal Transduction" for the October 1 issue.
  14. Wang, Z.and Moran, M. (2002)Phospholipase C-1: a Phospholipase and Guanine Nucleotide Exchange Factor.Molecular Intervention2: 352-355
  15. Chen, X. andWang, Z.(2001) Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase.EMBO Reports2: 842-849.
  16. Chen, X. andWang, Z.(2001)Regulation of EGF receptor intracellular trafficking by Rab5 in the absence of Phosphatidylinosito 3-kinase activity.EMBO Reports2:68-74. (with Cover Illustration)
  17. Dankort, D., Maslikowski, B., Warner, N., Kanno N. Kim, H.,Wang, Z.,Moran, M.F., Oshima, R.G., Cardiff, R. D. and Muller, W. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer.Mol. Cell. Biol.21:1540-1551.
  18. Chen, X., Yeung, K. T. and Wang, Z. (2000)Enhanced drug resistance in cells coexpressing ErbB2 with EGFR or ErbB3.Biochem. Biophys. Res. Commun.277: 757-763.

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