Sai Ming Ngai
School of Life Sciences, the Chinese University of Hong Kong SAR, China
Associate Professor
The Chinese Medicinal Fungal Proteomics Laboratory, the Chinese University of Hong Kong, China
Director
State Key Laboratory for Agrobiotechnology, the Chinese University of Hong Kong,China
Principle Investigator
Email: smngai@cuhk.edu.hk
Qualifications
1988 – 1994 Ph.D. (Biochemistry) University of Alberta, Edmonton, Canada
1984 – 1986 B.Sc. (Honors Biochemistry, Dean’s Honor List) University of Waterloo, Waterloo, Canada
Publications(Selected)
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Shao, J., Xu, D., Hu, L., Kwan, Y. W., Wang, Y., Kong, X.,Ngai, S.M., (2012) Systematic analysis of human lysine acetylation proteins and accurate prediction of human lysine acetylation through bi-relative adapted binomial score Bayes feature representation. Mol Biosyst. 2012 Oct 2;8(11):2964-73. doi: 10.1039/c2mb25251a.
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Wang, C., Lu, Y. Chen, Z., Liu, X., Lin, H., Zhao, H., Chen, J., Kwan, Y.W.,Ngai, S.M. (2012) Serum proteomic, peptidomic and metabolomic profiles in myasthenia gravis patients during treatment with Qiangji Jianli Fang. Chinese Medicine 2012, 28 July 2012:7:16
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Poon, T.C., Pang, R.T., Chan, K.C., Lee, N.L., Chiu, R.W., Tong, Y.K., Chim, S.S.,Ngai, S.M., Sung, J.J., Lo, Y.M. (2012) Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome. Electrophoresis. 2012 Jul;33(12):1894-900. doi: 10.1002/elps.201200002.
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Lu, Y., Zheng, Y., Liu, X., Liang, X.,Ngai, S.M., Tiejun Li, T., and Zhang, W. (2012)Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B.Chinese Medicine2012, 7:6 doi:10.1186/1749-8546-7-6
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Wu T., Pi E.X., Tsai S.N., Lam H.M., Sun S.M., Kwan Y.W.,Ngai, S.M.(2011) GmPHD5 acts as an important regulator for crosstalk between histone H3K4 di-methylation and H3K14 acetylation in response to salinity stress in soybean. BMC Plant Biol. 2011 Dec 15;11:178. PMID: 22168212 [PubMed -in process]
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Chan P.K., Ma S.,Ngai, S.M.(2011) Identification of T-cell epitopes of SARS-coronavirus for development of peptide-based vaccines and cellular immunity assessment methods. Hong Kong Med J. 2011 Dec;17 Suppl 6:26-30. PMID: 22147356 [PubMed - in process]
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Lu, Y., Chunmei Wang, C.M., Chen, Z., Zhao, H., Chen, J. b, Xiaobin Liu, X., Kwan, Y.W., Lin, H. andNgai, S.M.(2011) Serum metabolomics for the diagnosis and classification of myasthenia gravisMetabolomics.Doi:10.1007/s11306-011-0364-6.
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Li, G., Zhang, X.A., Wang, H., Wang, X., Meng, C.L., Chan, C.Y., Yew, D.T., Tsang, K.S., Li, K., Tsai, S.N., Ngai, S.M., Han, Z.C., Lin, M.C., He, M.L., Kung, H.F. (2011) Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord and placenta: implication in the migration. Adv Exp Med Biol. 2011;720:51-68.
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Poon, C.C., Seto S.W., Au A.L., Zhang Q, Li, R.W., Lee, W.Y., Leung, G.P., Kong, S.K., Yeung, J.H.,Ngai, S.M.,Ho, H.P., Lee, S.M., Chan, S.W., Kwan, Y.W. (2010) Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery.Br J Pharmacol.161:1086-1098. doi: 10.1111/j.1476-5381.2010.00941.x.
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Zhang, L., Lam, W.P., Lü, L., Wang, C., Wong, Y.W., Lam, L.H., Tang, H.C., Wai, MS, Wang, M, Kwong, WH,Ngai, S.M., Mak, YT, Yew, DT. (2010) Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke.Chin Med.5: 35.
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Peng, L., Kapp, E.A., Fenyö, D., Kwon, M.S., Jiang, P., Wu, S., Jiang, Y., Aguilar, M.I., Ahmed, N., Baker, M.S., Cai, Z., Chen, Y.J., Van, Chi. P., Chung, M.C., He, F., Len, A.C., Liao, P.C., Nakamura, K.,Ngai, S.M.,Paik, Y.K., Pan, T.L., Poon, T.C., Salekdeh, G.H., Simpson, R.J., Sirdeshmukh, R., Srisomsap, C., Svasti, J., Tyan, Y.C., Dreyer, F.S., McLauchlan, D., Rawson, P., Jordan, T.W. (2010) The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of thecarbonate-washed membrane standard.Proteomics.10: 4142-41428.
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Cheng, T.C., Chen, Y.W., Wong, K.B.,Ngai, S.M.,Chan, H.Y. (2010) Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis.Acta Crystallogr Sect F Struct Biol Cryst Commun. 66: 546-548.
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Wong, M.Y., Yu, K.O., Poon, T.C., Ang, I.L., Law, M.K., Chan, K.Y., Ng, E.W.,Ngai, S.M.,Sung, J.J., Chan, H.L. (2010) A magnetic bead-based serum proteomic fingerprinting method for parallel analytical analysis and micropreparative purification.Electrophoresis. 31: 1721-1730.
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Zhang, L., Lam, W., Lu, L., Wang, C., Wong, Y., Lam, L., Tang, H., Wai, M., Wang, M., Kwong, W.,Ngai, S.M.,Mak, Y. and Yew, D. (2010) Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke. Chinese Medicine 2010, 5:35 (18 October 2010)
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Seto, S.W., Lam, T.Y., Or, P.M., Lee, W.Y., Au, A.L., Poon, C.C., Li, R.W., Chan, S.W., Yeung, J.H., Leung, G.P., Lee, S.M.,Ngai, S.M.,Kwan, Y.W. (2010) Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice.J Nutr Biochem. 21: 872-880.
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Cui, S., Hu, J., Yang, B., Shi, L., Huang, F., Tsai, S.N.,Ngai, S.M., He, Y. and Zhang, J. (2009) Proteomic characterization of Phragmites communis in ecotypes of swamp and desert dune.Proteomics. 9: 3950-3967.
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Ma, Y., Yu, J., Chan, H.L., Chen, Y.C., Wang, H., Chen, Y., Chan, C.Y., Go, M.Y., Tsai, S.N.,Ngai, S.M., To, K.F., Tong, J.H., He, Q.Y., Sung, J.J., Kung, H.F., Cheng, C.H. and He, M.L. (2009) Glucose-Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus.Mol Cell Proteomics. 8: 2582-2594.
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Wu, T., Yuan, T., Tsai, S.N., Wang, C., Sun, S.M., Lam, H.M. andNgai, S.M.(2009) Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications.BMC Plant Biol. 9: 98.
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Lam, T.Y., Seto, S.W., Au, A.L., Poon, C.C., Lam, A.H., Lau, M.W., Chan, S.W.,Ngai, S.M., Leung, G.P., Lee, S.M., Tsui, S.K. and Kwan, Y.W. (2009) Folic Acid Supplementation Modifies {beta}-Adrenoceptor-Mediated in vitro Lipolysis of the Obese/Diabetic (+db/+db) Mice.Exp Biol Med(Maywood). 234: 1047-1055.
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Wang, C.M., Tsai, S.N., Yew, T.W., Kwan, Y.W. andNgai, S.M.(2010) Identification of histone methylation multiplicities patterns in the brain of senescence-accelerated prone mouse 8.Biogerontology.11: 87-102.
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Shao, J., Xu, D., Tsai, S.N., Wang, Y. andNgai, S.M.(2009) Computational identification of protein methylation sites through bi-profile Bayes feature extraction.PLoS ONE. 2009; 4(3):e4920.
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Seto, S.W., Lam, H.Y., Lau, W.S., Au, A.L., Lam, T.Y., Chim, S.S.,Ngai, S.M., Chan, S.W., Leung, T.Y., Yeung, J.H., Kong, S.K., Leung, G.P., Lee, S.M. and Kwan, Y.W. (2009) Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery.Eur J Pharmacol.605: 129-137.
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Li, G., Zhang, X.A., Wang, H., Wang, X., Meng, C.L., Chan, C.Y., Yew, D.T., Tsang, K.S., Li, K., Tsai, S.N.,Ngai, S.M., Han, Z.C., Lin, M.C., He, M.L. and Kung, H.F. (2009) Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: implication in the migration.Proteomics9: 20-30.
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Seto, S.W., Lam, T.Y., Tam, H.L., Au, A.L., Chan, S.W., Wu, J.H., Yu, P.H., Leung, G.P.,Ngai, S.M., Yeung, J.H., Leung, P.S., Lee, S.M. and Kwan, Y.W. (2009) Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.Phytomedicine. 16: 426-436.
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Chu, L.H.M., Chan, S.H., Tsai, S.N., Wang, Y., Cheng, C.H.K., Wong, K.B., Waye, M.M.Y. andNgai, S.M.(2008) Fusion Core Structure of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV): In Search of Potent SARS-CoV Entry Inhibitors. J. Cell Biochem.2008 Apr 28 [Epub ahead of print]
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Qi, Y.J., He, Q.Y., Ma, Y.F., Du, Y.W., Liu, G.C., Li, Y.J., Tsao, G.S.,Ngai, S.M., Chiu, J.F. (2008) Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma.J Cell Biochem.2008 Mar 4 [Epub ahead of print]
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Fu, L., Qin, Y.R., Xie, D., Chow, H.Y.,Ngai, S.M., Kwong, D.L., Li, Y. and Guan, X.Y. (2007) Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches.Cancer. 2007 Oct 24; [Epub ahead of print]
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Chen, Y., Lin, M.C., Wang, H., Chan, C.Y., Jiang, L.,Ngai, S.M., Yu, J., He, M.L., Shaw, P.C., Yew, D.T., Sung, J.J., Kung, H.F. (2007) Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma.Proteomics. Aug 6; [Epub ahead of print]
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Seto, S.W., Lam, T.Y., Leung, G.P., Au, A.L.,Ngai, S.M., Chan, S.W., Kwan, Y.W. (2007) Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice. Eur J Pharmacol. 2007 Jun 14; [Epub ahead of print]
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Kwok, C.S.Y., Siu, A.F.Ngai, S.M., Che, C.M. and Tsang J.S.H. (2007) Proteomic analysis of Burkholderia cepacia MBA4 in the degradation of monochloroacetate.Proteomics.Mar 13; [Epub ahead of print]
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