Dr. Xuanyong Lu

Email: Xuanyong.lu@ihvr.org

Qualifications

1994  Post-Doctor, Institute for Medical Virology of University Giessen

1989  Ph.D., Gottingen University, Virology

1982 bachelor of Science, Nanjing University, Biochemistry

Publications(Selected)

1. Lu Xuanyong and Zen Qinyi, Current Advances on the Studies of structure and Function of Alpha-fetoprotein (AFP). Shengwuhuaxue yu Shengwuwuli Jinzhan (Biochemistry and Biophysics), (38), 1-6. 1984
2. Lu Xuanyong, Yao Guangbi and Tien Yufen. A Study on the Relationship between HBV particle and PHSA Receptor. Shanghai Medical Journal, 4, 219-222. 1986
3. Yao Guangbi,Lu Xuanyong, Chang Liming, and Tien Yufen. Relationship between Products of HBV PreS Gene and Viral Replication. Chinese Journal of Infectious Disease, 4(3),125-130. 1986
4. Lu Xuanyong, Yao Guangbi, and Zheng Liming. Research on HBV albumin Receptor and its antibody. Hepatitis Research, 5,7-9,. 1987
5. Lu Xuanyong, Yao Guangbi and Tien Yufen. ”Reaction between Serum Albumin and Dane Particle" Chinese Journal of Infectious Disease. 5(2), 211-219. 1987
6. Lu Xuanyong, Yao Guangbi, and Zheng Ligang. Inhibition of Human Serum Albumin to Reaction between PHSA and its Receptor. Hepatitis Research, 5, 9-11. 1987
7. Lu Xuanyong, Yao Guangbi and Tien Yufen. The Interaction between Native Serum Albumin and Hepatitis B Virus. Arch. of Virol. 98,163-170. 1988
8. Lu Xuanyong,Yao Guangbi et. al. Detection of PreSI and PreS2 Proteins: New Marks of Replication. Chinese Journal of Infectious Disease, 6(4), 193-197,1988
9. Lu Xuanyong, Yao Guangbi, Zhen Liguang, and Wu Xiaohong, The binding characteristics of HBV albumin receptor, Shanghai J Immunol 9(6): 321, 1989
10. Wang Yuan, Wang Shaoqin, Feng Zongming, Zhou Wuwei, Kong Yuying, Zhu Shenzu, Li Zaiping,Lu Xuanyong, Yao Guangbi. Secretory expression of HBsAg preS in vaccinia virus system. Science in China (B Compilation), 1989; (11): 1161
11. Krone B., Lenz A., Heermann H., Seifer M.,Lu Xuanyong, Gerlich W.H., Interaction between Hepatitis B surface proteins and monomer human serum albumin. Hepatology, 1(6),1050-1056, 1990
12. Gerlich W. H., Deepen R., Heermann K. H., Krone B.,Lu Xuanyong, Seifer M., Thomssen R., Protective potential of hepatitis B virus antigen other than the S gene protein" Vaccine, Vol. 8, Supplement. 1990
13. Gerlich W. H.,Lu Xuanyong, Heermann K. H. Study on the attachment and perpetration of Hepatitis B virus. Journal of Hepatology 17, (3) S. 10-14. 1992
14. Gerlich W. H.,Lu Xuanyong. Binding of Hepatitis B surface protein to cell membranes. Journal of Hepatology. 16. S 1. 12. 1992
15. Gerlich W. H.,Lu Xuanyong, Heermann K. H. Study on the attachment and penetration of Hepatitis B virus. Journal of Hepatology 17, (3) S. 10-14. 1993
16. Meisel H. Sominskaya I. Pumpens P. Pushko P. Borisova G. Deepen R.Lu X. Spiller GH. Kruger DH. Grens E. et al. Fine mapping and functional characterization of two immuno-dominant regions from the preS2 sequence of hepatitis B virus. Intervirology. 37(6):330-9. 1994
17. Bruss V.,Lu Xuanyong., Thomssen R., Gerlich W. H. Posttranslational alterations in transmenbrance topology of the hepatitis B virus large envelope protein. EMBO J., 13. 2273-2279. 1994
18. Block T.,Lu Xuanyong, Frances M. Platt, Graham R. Foster, Wolfram H. Gerlich, Baruch S. Blumberg and Raymond A. Dwek. The secretion of human hepatitis B virus is inhibited by the imino sugar, N-butyldeoxynojirimycin. PNSA, USA 91. 2235-2239 1994. 1994
19. Kann, M.,Lu X.,Gerlich W. H. Recent studies on replication of Hepatitis B virus. Journal of Hepatology. 22 (1 suppl.), 9-13. 1995
20. Lu Xuanyong, Anand Metha, Raymond Dwek, Terry Butters and Timothy Block. Evidence the N-linked glycosylation is necessary for hepatitis B virus secretion. Virology. 213. 660-665. 1995
21. Lu Xuanyong, Block T., Gerlich W.H. Protease-induced infectivity of hepatitis B virus for a human hepatoma cell line. J. Viriol. 70, 2277-2285. 1996
22. Mehta A.,Xuanyong Lu, T. Block, B. Blumberg and R. Dwek. Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion. Proc. Natl. Acad. Sci. USA 94 1822-1827. 22. 1997
23. Lu Xuanyong, Anand Metha, Dadmarz M. Dwek .R. Blumberg .B. and T. Block. Aberrant trafficking of hepatitis b virus glycoproteins in which N-glycan processing is inhibited. PNAS USA 94 2380-2385, 1997
24. Block TM.Lu X. Mehta A. Park J. Blumberg BS. Dwek R. Role of glycan processing in hepatitis B virus envelope protein trafficking. Advances in Experimental Medicine & Biology. 435:207-16, 1998
25. Timothy Block,Xuanyong Lu, Anand Mehta, Brauch S. Blumburg, Bud Tennant, Mathew Ebling, Brent korba, David Lansky, Gray S. Jacob, and Raymond Dwek. Treatment of Hepatitis virus in chronically infected woodchucks with folding and trafficking inhibitor. Nature Medicine. Vol. 4, No. 5, 610-614. 1998

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