Prof. Zhixiang Wang

Department of Cell Biology

Faculty of Medicine and Dentistry

University of Alberta, Canada

Email: zhixiang.wang@ualberta.ca

Qualifications

1989-1993   Ph.D., Biochemistry, Simon Fraser University, Canada
1982-1985   M.S., Zoology, Academia Sinica, China
1978-1982   B.S., Biology, Beijing University, China
 
Publications (Selected)

1. Chen C., Uludag H., Wang Z., Rezansoff A., Jiang H. (2011) inhibit migration, metabolic activity and osteogenic differentiation of human mesenchymal stem cells in vitro.Cells Tissues Organs (in press) 
2. Liu, L., Shi, H., Chen, X. and Wang, Z. (2011) Regulation of EGF Receptor Endocytosis during Mitosis.Traffic 12: 201-217.  
3. Pahara, J., Shi, H., Chen, X. and Wang, Z. (2010) Dimerization Drives PDGF Receptor Endocytosis through a C-terminal Hydrophobic Motif Shared by EGF Receptor. Exp. Cell Res 15: 2237-50. 
4. Li, S, Wang, Q, Wang,Y. Chen, X. and Wang, Z. (2009) PLC-γ1 and Rac1 co-regulates EGF-induced cytoskeleton remodelling and cell migration. Molecular Endocrinology 23: 901-913. 
5. Pennock, S. and Wang, Z. (2008) A Tale of Two Cbls:  Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation. Mol. Cell. Biol. 28: 3020-3037. 
6. Wang, Q., Wu, F., and Wang, Z. (2007) Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif ¹⁰¹⁰LL¹⁰¹¹ as Essential in EGF Receptor Endocytosis. Exp. Cell Res. 313: 3349-3363. 
7. Wang, Y., Wu, J. and Wang, Z. (2006) Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor. Mol. Biol. Cell 17: 2267-2277. 
8. Wang, Q., Villeneuve, G., and Wang, Z. (2005) Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation. EMBO Rep., 6: 942-948. 
9. Wang, Y., Pennock, S., Chen, X.,  Kazlauskas, A. and Wang, Z. (2004) PDGF receptor-mediated signal transduction from endosomes. J. Biol. Chem. 279: 8038-8046 
10. Wang, Y. and Wang, Z. (2003) Regulation of EGF-induced phospholipase   C-1 translocation and activation by its SH2 and PH domains. Traffic 4: 618-630 
11. Pennock, S. and Wang, Z. (2003) Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling. Mol. Cell. Biol. 23: 5803-5815       
12. Wang Y, Pennock S, Chen X. and Wang Z.. Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Sci. STKE 2002(161): PL17 . 
13. Wang, Y., Pennock, S, Chen, X. and Wang, Z. (2002) Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival. Mol. Cell. Biol. 22 (20): 7279-7290 [Cover illustration on MCB 22 (22)]. Science's STKE highlighted this paper in "This Week in Signal Transduction" for the October 1 issue. 
14. Wang, Z. and Moran, M. (2002) Phospholipase C-1: a Phospholipase and Guanine Nucleotide Exchange Factor. Molecular Intervention 2: 352-355 
15. Chen, X. and Wang, Z. (2001) Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase. EMBO Reports 2: 842-849. 
16. Chen, X. and Wang, Z. (2001) Regulation of EGF receptor intracellular trafficking by Rab5 in the absence of Phosphatidylinosito 3-kinase activity. EMBO Reports 2:68-74. (with Cover Illustration) 
17. Dankort, D., Maslikowski, B., Warner, N., Kanno N. Kim, H., Wang, Z., Moran, M.F., Oshima, R.G., Cardiff, R. D. and Muller, W. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer. Mol. Cell. Biol. 21: 1540-1551. 
18. Chen, X., Yeung, K. T. and Wang, Z. (2000) Enhanced drug resistance in cells coexpressing ErbB2 with EGFR or ErbB3. Biochem. Biophys. Res. Commun. 277: 757-763.