Associate Research Scientist

Email: pb2452@columbia.edu

Qualifications

1987    Laurea in Biology (PhD equivalent), University of Milan, Italy
1985    Technician in Environmental and Industrial Chemistry, University of Turin, Italy
 

Publications (Selected)

1.  Parisi, F., Riccardo, N. Daniel, M. Saqcena, M. Kundu, N. Pession, A., Grifoni, D. Stocker, H. Tabak, E and Bellosta, P. “Drosophila insulin and target of rapamycin (TOR) pathways converge on GSK3β activity to control Myc protein stability and to determine growth in vivo” BMC Biology 2011 Sept 9:65. 
2. Ziosi, M. Baena-López, AL. Froldi, F. Garoia, F. Trotta, V. Bellosta P, Grifoni, G. Pession, A. and Cavicchi, S. “dMyc function downstream Yorkie reveals new rules for cell competition and adds complexity to the Hpo pathway” PLoS Genet. 2010 Sep 23;6 (9).  
3. Paola Bellosta & Peter Gallant “Myc function in Drosophila” review Genes Cancer 2010 1:(6):542-546.
4. Froldi, F. Ziosi M, Garoia, F. Pession, A. Grzeschik, N. Bellosta, P. Strand, D. Richardson, HE. Pession, A. and Grifoni D. “The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy”BMC Biology 2010 Apr 7;8:33. 
5. Galletti, M. Riccardo, S. Parisi, F. Lora, C. Saqcena, MK. Rivas, L. Wong, B. Serra, A. Serras, F. Grifoni, D. Pelicci, PG. Jiang, J. and Bellosta P. “Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase 3beta and casein kinases 1 kinases” Mol Cell Biol. 2009; 29:3424-34. 
6. Raucci, A. Bellosta, P. Grassi, R. Basilico, C. and Mansukhani A. “Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways” J Cell Physiol. 2008; 215:442-51. 
7. Grifoni, D. Garoia, F. Bellosta, P. Parisi, F. De Biase, D. Collina, G. Strand, D. Cavicchi, S. and Pession A. “aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia” Oncogene. 2007; 26:5960-65. 
8. Bellosta, P. Hulf,T. Balla Diop, S. Usseglio, F. Pradel, J. Aragnol, D. and Gallant P. “Myc interacts genetically with Tip48 and Tip49 to control growth and proliferation during Drosophila development” Proc Natl Acad Sci U S A. 2005; 102:11799-804. 
9. Hulf, T. Bellosta, P. Furrer, M. Steiger, D. Svensson, D. Barbour, A. and Gallant P. “Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes” Mol Cell Biol. 2005; 25:3401-10. 
10. Sainaghi, PP. Castello, L. Bergamasco, L. Galletti, M. Bellosta, P. and Avanzi GC. “Gas6 induces proliferation in prostate carcinoma cell lines expressing the axl receptor” J Cell Physiol. 2005; 204:36-44.
11. de la Cova C, Abril M, Bellosta, P, Gallant, P. and Johnston LA. “Drosophila myc regulates organ size by inducing cell competition” Cell. 2004;117:107-16. 
12. Bellosta, P. Masramon, L. Mansukhani, A. and Basilico C. “p21 WAF1/Cip1 acts as a brake in osteoblast differentiation” J Bone Miner Res 2003; 18: 818-826. 
13. Bellosta, P. Iwahori, A. Plotnikov, AN. Eliseenkova, AV. Basilico, C. and Mohammadi M. “Identification of Receptor and Heparin Binding Sites in FGF4 by Structure-Based Mutagenesis” Mol Cell Biol. 2001; 21:5946-5957. 
14. Mansukhani, A*. Bellosta, P*. Sahni, M. and Basilico C. “Signaling by FGF and FGFR-2 activating mutations induces apoptosis and block mineralization in calvarial osteoblasts” J Cell Biol. 2000; 149: 1297-308. *equally contributed 
15. Allen, MP. Zeng, C. Schneider, K. Xiong, X. Meintzer, MK. Bellosta, P. Basilico, C. Varnum, B. Heidenreich, KA. And Wierman ME. “Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropinreleasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt” Mol Endocrinology 1999; 13:191-201. 
16. Bellosta, P. Zheng, Q. Goff, S. and Basilico C. “Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation” Oncogene 1997; 15:2387-2397. 
17. Guthridge, MA. Bellosta, P. Tavoloni, N. and Basilico C. “FIN13, a novel growth factor-inducible serine/threonine phosphatase, which can inhibit cell cycle progression” Mol Cell Biol. 1997; 17: 5485-5498. 
18. Schwenger P., Bellosta P., Vietor I., Basilico C., Skolnik E. and Vilcek J. “Sodium salicylate induces apoptosis via p38 MAP kinase activation but inhibits TNF-induced JNK/SAPK activation” Proc Nat Acad Sci. USA 1997; 94: 2869-2873. 
19. Costa, M. Bellosta, P. and Basilico C. “Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vivo and in vitro” J Cell Physiol. 1996; 168:737-744. 
20. Bellosta, P. Costa, M. Lin, AD. and Basilico C. “The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding” Mol Cell Biol. 1995; 15:614-625. 
21. Roghani, M. Dell'Era, P. Mansukhani, A. Bellosta, P. Basilico, C. Rifkin, D. and Moscatelli D. “Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding” J Biol Chem. 1994; 269:3976-3984. 
22. Bellosta, P. Talarico, D. Rogers, D. and Basilico C. “Cleavage of K-FGF produces a truncated molecule with increased biological activity and receptor binding affinity” J. Cell Biol. 1993; 121:705-713. 
23. Vainikka, S. Partanen, J. Bellosta, P. Coulier, F. Basilico, C. Jaye, M. and Alitalo K. “Fibroblast growth factor receptor-4 (FGFR-4) shows novel features in genomic structure, ligand binding and signal transduction” EMBO J. 1992; 11:4237-4280. 
24. Legname, G. Bellosta, P. Gromo G. Modena, D. Keen, JF. Roberts, LM. and Lord JM. “Nucleotide sequence of cDNA coding for dianthin 30, a ribosome inactivating protein from Dianthus Caryophyllus” Biochimica et Biophysica Acta 1991; 1090: 3551-55.
25. Miotti, S. Mantovani, L. Pupa, S. Bellosta, P. and Colnaghi MI. “Characterization of two anti-idiotypic monoclonal antibodies raised against the anti-tumor monoclonal antibody MOV 18” Journal Immunological Research 1989; 1:59-65.