Biography

Dr. Andrea De Gottardi

Department of Clinical Research

University of Berne, Switzerland


Hepatology

University Clinic of Visceral Surgery and Medicine, Switzerland


Email: andrea.de-gottardi@alumni.uni-heidelberg.de


Qualifications

2002 Ph.D., University of Berne, Switzerland

1999 M.Sc., University of Berne, Switzerland

1994 B.Sc., University of Lausanne, Switzerland


Publications

  1. De Gottardi, L. Krähenbühl, J. Fahradi, S. Gernhardt, M. Schäfer and M.W. Büchler. Clinical Experience of Feeding Through a Needle Catheter Jejunostomy after Major Abdominal Operations . Eur J Surg 1999; 165: 1055-1060.
  2. P. Lahaye, L. Fouassier, K.A. Tazi, A. De Gottardi, J-F. Fléjou, C. Chagneau, J-P.Rona, C. Housset, J. Reichen, D. Lebrec, R.Moreau. Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis. J Hepatol. 1999; 30:107-114.
  3. F. Ruschitzka, T. Quaschning, G. Noll, A. De Gottardi, M.F. Rossier, F. Enseleit, D. Hürlimann, T.F. Lüscher, S. Shaw. Endothelin 1 type A receptor antagonism prevents vascular dysfunction and hypertension induced by -hydroxysteroid dehydrogenase inhibition. Role of nitric oxide. Circulation.b11 2001; 103: 3129-3135.
  4. A.De Gottardi, S. Shaw, H. Sägesser and J. Reichen. Type A, but not type B endothelin receptor antagonists cause a significant decrease of portal pressure in portal hypertensive rats. J Hepatol. 2000. 33:733-737.
  5. S. Tièche*, A. De Gottardi*, A. Kappeler, S. Shaw, H. Sägesser, A. Zimmermann, J. Reichen. Overexpression of endothelin-1 in bile duct ligated rats: correlation with activation of hepatic stellate cells and portal pressure.*authors contributed equally. J Hepatol. 2001; 34: 38-45.
  6. A.De Gottardi, F. Touri, C.A. Maurer, O. Maurhofer, A. Perez, G. Ventre, C.L. Bentzen, E.J. Niesor, J-F. Dufour. The bile acid nuclear receptor FXR and the bile acid binding protein IBABP are differently expressed in colon cancer. Digest Dis Sci. 2004; 49: 982–989.
  7. K. Abid, V. Pazienza, A. De Gottardi, L. Rubbia-Brandt, B. Conne, P. Pugnale, C. Rossi, A. Mangia, F. Negro. An in vitro model of hepatitis C virus genotype 3-associated triglyceride accumulation. J Hepatol. 2005; 42(5): 744-51.
  8. E. Biecker, A. De Gottardi, M.Neef, M. Unternährer, V. Schneider, M. Ledermann, H. Sägesser, J. Reichen. Long-term treatment of bile duct ligated rats with rapamycin significantly attenuates liver fibrosis: analysis of the underlying mechanisms. J Pharmacol Exp Ther. 2005; 313(3): 952-61.
  9. A.Koshy, A. De Gottardi, M. Ledermann, H. Sägesser, S. Shaw, A. Zimmermann, J. Reichen. Endothelial nitric oxide synthase is not essential for the development of fibrosis and portal hypertension in bile duct ligated mice. Liver Int. 2005; 25(5): 1044-52.
  10. De Gottardi, V. Pazienza, P. Pugnale, F. Bruttin, L. Rubbia-Brandt, C.E. Juge-Aubry, C.A. Meier, A. Hadengue, F. Negro. Peroxisome proliferator-activated receptor a and g mRNAs levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection. Aliment Pharm Ther. 2006; 23(1): 107-14.
  11. P. Pugnale, P. Latorre, C. Rossi, K. Crovatto, V. Pazienza, A. De Gottardi, F. Negro. Real-time multiplex PCR assay to quantify hepatitis C virus RNA in peripheral blood mononuclear cells. J Virol Methods. 2006; 133(2): 195-204.
  12. A.De Gottardi, J-M. Dumonceau, F. Bruttin, A. Vonlaufen, I. Morard, L. Spahr, L. Rubbia-Brandt, J-L. Frossard, W.N.M. Dinjens, P.S. Rabinovitch, A. Hadengue. Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. Molecular Cancer. 2006; 5: 48.
  13. De Gottardi, E. Biecker, A. Koshy, D. Bohler, S. Shaw, H. Sägesser, J. Reichen. Sensitivity to endothelin-1 is decreased in isolated livers of endothelial constitutive nitric oxide synthase knockout mice. Comp Hepatol. 2006; 5; 5: 9.
  14. De Gottardi, M. Vinciguerra, A. Sgroi, M.Moukil, F. Ravier Dall’Antonia, V. Pazienza, P. Pugnale, M. Foti, A. Hadengue. Microarray analyses and molecular profiling of steatosis induction in immortalized fatty hepatocytes. Lab Invest. 2007; 87, 792–806.
  15. De Gottardi, L. Spahr, P. Gelez, I. Morard, G. Mentha, O. Guillod, P. Majno, Ph. Morel, A. Hadengue, P. Paliard, JY. Soazec, O. Boillot, E. Giostra, J. Dumortier. A simple score for predicting alcohol relapse after liver transplantation. Arch Intern Med. 2007; 167(11): 1183-88.
  16. Tiani, E. Garcia-Pras, M. Mejias, A. De Gottardi, A. Berzigotti, J. Bosch, M. Fernandez. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension. J Hepatol. 2009; 50(2): 296-305.
  17. De Gottardi, T. Thévenot, L. Spahr, I. Morard, S. Bresson-Hadni, F. Torres, E. Giostra, A. Hadengue. Risk of complications after abdominal paracentesis in cirrhotic patients: a prospective study. Clinical gastroenterology and hepatology. 2009; 7(8): 906-9.
  18. De Gottardi, M-N. Hilleret, P. Gelez, V. La Mura, O. Guillaud, P. Majno, A. Hadengue, P. Morel, J-P. Zarski, M. Fontana, D. Moradpour, G. Mentha, O. Boillot, V. Leroy, E. Giostra, J. Dumortier. Injection drug use before and after liver transplantation: a retrospective multicenter analysis on incidence and outcome. Clin Transplant. 2010; 24(4): 564-71.
  19. Berzigotti*, P. Bellot*, A. De Gottardi*, J. Abraldes, J-C. Garcia-Pagan, C. Gagnon, J. Spénard, J. Bosch. NCX-1000, a nitric oxide-releasing derivative of UDCA does not decrease portal pressure in patients with cirrhosis. Results of a randomized, double-blind, dose escalating study. *authors contributed equally. Am. J. Gastroenterology. 2010; 105(5): 1094-101.
  20. De Gottardi, L. Spahr, F. Ravier-Dall’Antonia, A. Hadengue. Cannabinoid receptor 1 and 2 agonism increases lipid accumulation in hepatocytes. Liver Int. 2010; 30(10): 1482-9.


Free SCIRP Newsletters
Copyright © 2006-2024 Scientific Research Publishing Inc. All Rights Reserved.
Top