Dr. Wange Lu

Department of Biochemistry and Molecular Biology

University of Southern California, USA
Assistant Professor

Email: wangelu@usc.edu

Qualifications

1990   B.S., Nankai University, China
1993   M.S., Beijing University, China
1998   Ph.D., Harvard University, UK 

Publications

1. Lu, W., Dang, W., Zhang, G., Zhu, Y and Chen, Z. (1994). Expression of Trichosanthin in Saccharomyces cerevisiae.   J Biotechnol  10(2), 173-177.
2. Dang, W., Lu, W., Cao, X., Pan N. and Chen, Z. (1994). Cloning of tomato polygalacturonase cDNA and transforming plants with antisense RNA.  Acta Botanica Sinica 36, 171-177.  
3. Lu, W., Katz, S., Gupta, R., and Mayer, B. J. (1997). Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol 7, 85-94.  
4. Tanaka, M., Lu, W., Gupta, R., and Mayer, B. J. (1997). Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development. Proc Natl Acad Sci U S A 94, 4493-4498.  
5. Evans, E. K., Lu, W., Strum, S. L., Mayer, B. J., and Kornbluth, S. (1997). Crk is required for apoptosis in Xenopus egg extracts. EMBO J 16, 230-241.  
6. Nikolic, M., Chou, M. M., Lu, W., Mayer, B. J., and Tsai, L. H. (1998). The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nature 395, 194-198.  
7. Anton, I. M., Lu, W., Mayer, B. J., Ramesh, N., and Geha, R. S. (1998). The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J Biol Chem 273, 20992-20995. 
8. Manninen, A., Hiipakka, M., Vihinen, M., Lu, W., Mayer, B. J., and Saksela, K. (1998). SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. Virology 250, 273-282. 
9. Lu, W., and Mayer, B. J. (1999). Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 18, 797-806.  
10. Lei, M., Lu, W., Meng, W., Parrini, M. C., Eck, M. J., Mayer, B. J., and Harrison, S. C. (2000). Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102, 387-397.  
11. Lu, W., Yamamoto, V., Ortega, B. and Baltimore, D. (2004). Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 119, 97-108.  
12. Lyu, J, Yamamoto, V, and Lu. W. (2008) Cleavage of Wnt Receptor Ryk Regulates Neuronal Differentiation During Cortical Neurogenesis. Developmental Cell. 5(5):773-80.  
13. Lyu, J., Wesselschmidt, RL and Lu, W (2009). Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain, Journal of Biological Chemistry, 284(19):12940-8 
14. Wei, Z., Yang, Y., Zhang, P., Andrianakos, R., Hasigawa, K., Lyu, J., Chen, X., Bai, G., Liu, C., Pera, M. and Lu. W (2009). Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells, 27(12):2969-78.  
15. Zhong, J.F., Weiner, L.P., Jin, Y, Lu W, Taylor, C.R. (2010): A real-time pluripotency reporter for human stem cell.  Stem Cells Dev., 19(1):47-52 
16. Zhang, P., Adrianakos, R., Yang, Y. and Lu, W (2010), Kruppel-like factor 4 (KLF4) prevents embryonic stem (ES) cell differentiation by regulating nanog gene expression., Journal of Biological Chemistry, 285(12): 9180-9. 
17. Hasegawa K, Zhang P, Wei Z, Pomeroy JE, Lu W, Pera MF (2010), Comparison of reprogramming efficiency between transduction of reprogramming factors, cell-cell fusion, and cytoplast fusion. Stem Cells, 28(8):1338-48.
18. Choi SH, Heo K, Byun HM, An W, Lu W, Yang AS (2011), Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Research. 39(1):104-18. 
19. Zhong, J., Kim, H., Lyu, J., Yoshikawa, K Nakafuku, M. and Lu, W (2011), Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development. Development, 138(3):409-19. 
20. Lyu, J., Jho, E. and Lu, W (2011), Smek promotes histone deacetylation to suppress transcription of Wnt target gene brachyury in pluripotent embryonic stem cells, Cell Research, 21(6):911-21. 
21. Choi J, Kim H, Kim K, Lee B, Lu W, An W. (2011), Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing, Nucleic Acids Res. epub Aug 16, 2011. 

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Last Updated: December 12, 2011.

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