Prof. X. Frank Yang
Department of Microbiology and Immunology
Indiana University School of Medicine, USA

Email: xfyang@iupui.edu

Qualifications
1997 Ph.D., The University of Texas at Dallas, USA
1994 M.S., The University of Texas at Dallas, USA

Publications (Selected)

1. Alakhras, N. S., Zhang, W., Barros, N., Sharma, A., Ropa, J., Priya, R., ... & Kaplan, M. H. (2024). An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation. Proceedings of the National Academy of Sciences, 121(32), e2400153121.
2. Raghunandanan, S., Priya, R., Alanazi, F., Lybecker, M. C., Schlax, P. J., & Yang, X. F. (2024). A Fur family protein BosR is a novel RNA-binding protein that controls rpoS RNA stability in the Lyme disease pathogen. Nucleic Acids Research, 52(9), 5320-5335.
3. Zhang, J. J., Raghunandanan, S., Wang, Q., Priya, R., Alanazi, F., Lou, Y., & Yang, X. F. (2024). BadR directly represses the expression of the glycerol utilization operon in the Lyme disease pathogen. Journal of Bacteriology, 206(2), e00340-23.
4. Alanazi, F., Raghunandanan, S., Priya, R., & Yang, X. F. (2023). The Rrp2-RpoN-RpoS pathway plays an important role in the blood-brain barrier transmigration of the Lyme disease pathogen. Infection and Immunity, 91(11), e00227-23.
5. Ring, K., Couper, L. I., Sapiro, A. L., Yarza, F., Yang, X. F., Clay, K., ... & Swei, A. (2022). Host blood meal identity modifies vector gene expression and competency. Molecular Ecology, 31(9), 2698-2711.
6. Bobe, J. R., Jutras, B. L., Horn, E. J., Embers, M. E., Bailey, A., Moritz, R. L., ... & Fallon, B. A. (2021). Recent progress in Lyme disease and remaining challenges. Frontiers in medicine, 8, 666554.
7. Samuels, D. S., Lybecker, M. C., Yang, X. F., Ouyang, Z., Bourret, T. J., Boyle, W. K., ... & Caimano, M. J. (2021). Gene regulation and transcriptomics. Current issues in molecular biology, 42(1), 223-266.
8. Couper, L. I., Yang, Y., Yang, X. F., & Swei, A. (2020). Comparative vector competence of North American Lyme disease vectors. Parasites & Vectors, 13, 1-11.
9. Zhang, Y., Chen, T., Raghunandanan, S., Xiang, X., Yang, J., Liu, Q., ... & Lou, Y. (2020). YebC regulates variable surface antigen VlsE expression and is required for host immune evasion in Borrelia burgdorferi. PLoS pathogens, 16(10), e1008953.
10. Gomes-Solecki, M., Arnaboldi, P. M., Backenson, P. B., Benach, J. L., Cooper, C. L., Dattwyler, R. J., ... & Schutzer, S. E. (2020). Protective immunity and new vaccines for Lyme disease. Clinical Infectious Diseases, 70(8), 1768-1773.
11. Chen, T., Xiang, X., Xu, H., Zhang, X., Zhou, B., Yang, Y., ... & Yang, X. F. (2018). LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen. Emerging Microbes & Infections, 7(1), 1-9.
12. Zhang, J. J., Chen, T., Yang, Y., Du, J., Li, H., Troxell, B., ... & Yang, X. F. (2018). Positive and negative regulation of glycerol utilization by the c-di-GMP binding protein PlzA in Borrelia burgdorferi. Journal of bacteriology, 200(22), 10-1128.
13. Zhou, B., Yang, Y., Chen, T., Lou, Y., & Yang, X. F. (2018). The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen. Ticks and tick-borne diseases, 9(5), 1343-1349.
14. Carrasco, S. E., Hu, S., Imai, D. M., Kumar, R., Sandusky, G. E., Yang, X. F., & Derbigny, W. A. (2018). Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL/6N mice. PLoS One, 13(4), e0195165.
15. Muhammad, S. A., Guo, J., Nguyen, T. M., Wu, X., Bai, B., Yang, X. F., & Chen, J. Y. (2018). Simulation study of cDNA dataset to investigate possible Association of Differentially Expressed Genes of human THP1-Monocytic cells in cancer progression affected by bacterial Shiga toxins. Frontiers in Microbiology, 9, 380.
16. Xiang, X., Yang, Y., Du, J., Lin, T., Chen, T., Yang, X. F., & Lou, Y. (2017). Investigation of ospC expression variation among Borrelia burgdorferi strains. Frontiers in cellular and infection microbiology, 7, 131.

Profile Details

WoS ResearcherID: GKL-0529-2022

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