Dr. Fabrice Porcheray

Immunology / Surgery

Harvard Medical School, USA

Instructor

Department of Surgery

Massachusetts General Hospital, USA

Research Associate

Email: fporcheray@partners.org

Qualifications

2005 Ph.D., Immunology, University of Paris, France.

2000 Pharm.D., University of Paris, France.

1997 M.Sc., Microbiology, University of Paris, France.

Publications

1. Hennequin, C., Porcheray, F., Waligora-Dupriet, A., Collignon, A., Barc, M., Bourlioux, P., and Karjalainen, T. 2001. GroEL (Hsp60) of Clostridium difficile is involved in cell adherence. Microbiology 147: 87-96.
2. Gras, G., Chretien, F., Vallat-Decouvelaere, A.V., Le Pavec, G., Porcheray, F., Bossuet, C., Leone, C., Mialocq, P., Dereuddre-Bosquet, N., Clayette, P., et al. 2003. Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain Pathol 13: 211-222.
3. Jorajuria, S., Dereuddre-Bosquet, N., Becher, F., Martin, S., Porcheray, F., Garrigues, A., Mabondzo, A., Benech, H., Grassi, J., Orlowski, S., et al. 2004. ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther 9: 519-528.
4. Rimaniol, A.C., Gras, G., Verdier, F., Capel, F., Grigoriev, V.B., Porcheray, F., Sauzeat, E., Fournier, J.G., Clayette, P., Siegrist, C.A., et al. 2004. Aluminum hydroxide adjuvant induces macrophage differentiation towards a specialized antigen-presenting cell type. Vaccine 22: 3127-3135.
5. Porcheray, F., Viaud, S., Rimaniol, A.C., Leone, C., Samah, B., Dereuddre-Bosquet, N., Dormont, D., and Gras, G. 2005. Macrophage activation switching: an asset for the resolution of inflammation. Clin Exp Immunol 142: 481-489.
6. Gras, G., Porcheray, F., Samah, B., and Leone, C. 2006. The glutamate-glutamine cycle as an inducible, protective face of macrophage activation. J Leukoc Biol 80: 1067-1075.
7. Leone, C., Le Pavec, G., Meme, W., Porcheray, F., Samah, B., Dormont, D., and Gras, G. 2006. Characterization of human monocyte-derived microglia-like cells. Glia 54: 183-192.
8. Porcheray, F., Leone, C., Samah, B., Rimaniol, A.C., Dereuddre-Bosquet, N., and Gras, G. 2006. Glutamate metabolism in HIV-infected macrophages: implications for the CNS. Am J Physiol Cell Physiol 291: C618-626
9. Porcheray, F., Samah, B., Leone, C., Dereuddre-Bosquet, N., and Gras, G. 2006. Macrophage activation and human immunodeficiency virus infection: HIV replication directs macrophages towards a pro-inflammatory phenotype while previous activation modulates macrophage susceptibility to infection and viral production. Virology 349: 112-120.
10. Zorn, E., Nelson, E.A., Mohseni, M., Porcheray, F., Kim, H., Litsa, D., Bellucci, R., Raderschall, E., Canning, C., Soiffer, R.J., et al. 2006. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108: 1571-1579
11. Bellucci, R., Oertelt, S., Gallagher, M., Li, S., Zorn, E., Weller, E., Porcheray, F., Alyea, E.P., Soiffer, R.J., Munshi, N.C., et al. 2007. Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis. Blood 109:2001-2007.
12. Samah, B., Porcheray, F., and Gras, G. 2008. Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol 151: 476-486.
13. Maneglier, B., Malleret, B., Guillemin, G.J., Spreux-Varoquaux, O., Devillier, P., Rogez-Kreuz, C., Porcheray, F., Therond, P., Dormont, D., and Clayette, P. 2009. Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages. Fundam Clin Pharmacol 23: 573-581.
14. Samah, B., Porcheray, F., Dereuddre-Bosquet, N., and Gras, G. 2009. Nerve growth factor stimulation promotes CXCL-12 attraction of monocytes but decreases human immunodeficiency virus replication in attracted population. J Neurovirol 15: 71-80.
15. Zorn, E., Mohseni, M., Kim, H., Porcheray, F., Lynch, A., Bellucci, R., Canning, C., Alyea, E.P., Soiffer, R.J., and Ritz, J. 2009. Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15: 382-388.
16. Porcheray, F., Wong, W., Saidman, S.L., De Vito, J., Girouard, T.C., Chittenden, M., Shaffer, J., Tolkoff-Rubin, N., Dey, B.R., Spitzer, T.R., et al. 2009. B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans. Am J Transplant 9: 2126-2135.
17. Wong, W., DeVito, J., Nguyen, H., Sarracino, D., Porcheray, F., Dargon, I., Pelle, P.D., Collins, A.B., Tolkoff-Rubin, N., Smith, R.N., et al. 2010 Chronic humoral rejection of human kidney allografts is associated with MMP-2 accumulation in podocytes and its release in the urine. Am J Transplant 10: 2463-2471.
18. Porcheray, F., DeVito, J., Yeap, B.Y., Xue, L., Dargon, I., Paine, R., Girouard, T.C., Saidman, S.L., Colvin, R.B., Wong, W., et al. 2010. Chronic humoral rejection of human kidney allografts associates with broad autoantibody responses. Transplantation 89: 1239-1246.
19. Gras, G., Samah, B., Hubert, A., Leone, C., Porcheray, F., and Rimaniol, A.C. 2011. EAAT expression by macrophages and microglia: still more questions than answers. Amino Acids
20. Porcheray, F., Miklos, D.B., Floyd, B.H., Sarantopoulos, S., Bellucci, R., Soiffer, R.J., Antin, J.H., Alyea, E.P., Ritz, J., and Zorn, E. 2011. Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. Transplantation 92: 359-365.