Prof. Adriana Bigi
Department of Chemistry
“Giacomo Ciamician”
Alma Mater Studiorum
University Of Bologna, Italy
Full Professor
Email: adriana.bigi@unibo.it
Qualifications
1975 Degree in
Chemistry, University of Bologna
Publications (selected)
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E. Boanini, P.
Torricelli, F. Sima, E. Axente, M. Fini, I.N. Mihailescu, A. Bigi. Strontium
and Zoledronate Hydroxyapatites Graded Composite Coatings for Bone Prostheses.
Journal of Colloid and Interface Science 2015; 448: 1-7.
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S. Amadori, P.
Torricelli, K. Rubini, M. Fini, S. Panzavolta, A. Bigi. Effect of sterilization
and crosslinking on gelatin films. J Mater Sci: Mater Med 2015; 26: 69.
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E. Boanini, P.
Torricelli, M. Gazzano, E. Della Bella, M. Fini, A. Bigi. Combined effect of
strontium and zoledronate on hydroxyapatite structure and bone cell responses.
Biomaterials 2014; 35: 5619-5626.
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S. Panzavolta, B.
Bracci, C. Gualandi, M.L. Focarete, E. Treossi, K. Kouroupis-Agalou, K. Rubini,
F. Bosia, L. Brely, N.M Pugno, V. Palermo, A. Bigi. Structural reinforcement
and failure analysis in composite nano fibers of graphene oxide and gelatin. Carbon 2014; 78: 566–577.
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A. Fiorani, C. Gualandi,
S. Panseri, M. Montesi, M. Marcacci, M.L. Focarete, A. Bigi. Comparative
performance of collagen nanofibers electrospun from different solvents and
stabilized by different crosslinkers. J Mater Sci: Mater Med 2014;
25: 2313–2321.
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S. Panzavolta, M.
Gioffre, B. Bracci, K. Rubini, A. Bigi. Montmorillonite Reinforced Type A
Gelatin Nanocomposites. J. Appl. Polym. Sci. 2014; 131, 40301.
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E. Boanini, P.
Torricelli, M. C. Cassani, G. A. Gentilomi, B. Ballarin, K. Rubini, F.
Bonvicini, A. Bigi. Cationic-anionic polyelectrolyte interaction as a tool to
graft silver nanoparticles on hydroxyapatite crystals and prevent cytotoxicity.
RSC Adv., 4, 2014; 645-652.
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P. Torricelli, M.
Gioffrè, A. Fiorani, S. Panzavolta, C. Gualandi, M. Fini, M L Focarete, A.
Bigi. Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of
mechanical 6 properties and chondrocyte response as a function of composition.
Mater. Sci. Eng., C 2014; 36: 130-138.
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E. Boanini, P.
Torricelli, M. Gazzano, M. Fini, A. Bigi. Crystalline Calcium Alendronate
Obtained by Octacalcium Phosphate Digestion: A New Chance for Local Treatment
of Bone Loss Diseases? 2013; 25: 4605–4611.
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S. Panzavolta, P.
Torricelli, S. Amadori, A. Parrilli, K. Rubini, E. della Bella, M. Fini, A.
Bigi. 3D interconnected porous biomimetic scaffolds: In vitro cell response. J
Biom Mat Res A 2013, 101A: 3560–3570.
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E. Boanini, P.
Torricelli, M. Gazzano, M. Fini, A. Bigi. The effect of alendronate doped
calcium phosphates on bone cells activity. Bone 2012, 51: 944–952.
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E. Boanini, M. Gazzano,
A. Bigi. Time Course of Zoledronate Interaction with Hydroxyapatite
Nanocrystals J. Phys. Chem. C 2012, 116: 15812−15818.
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E. Boanini, P.
Torricelli, M. Fini, F. Sima, N. Serban, I.N. Mihailescu, A. Bigi. Magnesium
and strontium doped octacalcium phosphate thin films by matrix assisted pulsed
laser evaporation. Journal of Inorganic Biochemistry 107, 2012; 65–72.
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E. Boanini, P.
Torricelli, M. Gazzano, M. Fini, A. Bigi. The effect of zoledronate-hydroxyapatite
nanocomposites on osteoclasts and osteoblast-like cells in vitro. Biomaterials
2012; 33: 722-730.
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E. Boanini, P.
Torricelli, M. Fini, A. Bigi. Osteopenic bone cell response to
strontium-substituted hydroxyapatite. Journal of Materials Science: Materials
in Medicine 2011; 22: 2079-208.
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E. Boanini, A. Bigi.
Biomimetic gelatin–octacalcium phosphate core–shell microspheres. Journal of
Colloid and Interface Science 2011; 362: 594–599.
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S. Panzavolta, B.
Bracci, K. Rubini, A. Bigi. Optimization of a biomimetic bone cement: Role of
DCPD. Journal of Inorganic Biochemistry 2011; 105: 1060–1065.
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S. Panzavolta, M.
Gioffrè, M. L. Focarete, C. Gualandi, L. Foroni, A. Bigi. Electrospun gelatin
nanofibers: optimization of genipin crosslinking to preserve fiber morphology
after exposure to water. Acta Biomater 2011; 7: 1702–1709.
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S. Panzavolta, P.
Torricelli, B. Bracci, M. Fini, A. Bigi. Functionalization of biomimetic
calcium phosphate bone cements with alendronate. J Inorg Biochem 2010; 104:
1099–1106.
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E. Boanini, M. Gazzano,
K. Rubini, A. Bigi. Collapsed Octacalcium Phosphate Stabilized by Ionic
Substitutions. Crys Growth Des 2010; 10: 3612–3617.
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E. Boanini, M. Gazzano,
A. Bigi. Ionic substitutions in calcium phosphates synthesized at low
temperature. Acta Biomater 2010; 6: 1882–1894.
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E. Boanini, S.
Panzavolta, K. Rubini, M. Gandolfi, A. Bigi. Effect of strontium and gelatin on
the reactivity of a-tricalcium phosphate. Acta Biomater 2010; 6: 936–942.
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E. Boanini, K. Rubini,
S. Panzavolta, A. Bigi. Chemico-physical characterization of gelatin films
modified with oxidized alginate. Acta Biomater 2010; 6: 383-388.
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B. Bracci, P.
Torricelli, S. Panzavolta, E. Boanini, R. Giardino, A. Bigi. Effect of Mg2+,
Sr2+, and Mn2+ on the chemico-physical and in vitro biological properties of
calcium phosphate biomimetic coatings. J Inorg Biochem 2009; 103: 1666–1674.
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A. Bigi, E. Boanini, C.
Capuccini, M. Fini, I.N. Mihailescu, C. Ristoscu, F. Sima, P. Torricelli.
Biofunctional alendronate–Hydroxyapatite thin films deposited by Matrix Assisted
Pulsed Laser Evaporation Biomaterials 2009; 30: 6168–6177.
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