Dr. Hui Mao

Emory University, USA

Email: hui.mao@emoryhealthcare.org

Qualifications

1989-1994 Ph.D., NMR/Biochemistry, Georgia State University

1985-1988 M.S., Physical Chemistry, Nanjing University

Publications (Selected)

1. Constantinidis I, Grant SC, Simpson NE, Oca-Cossio JA, Sweeney CA, Mao H, Blackband, SJ and Sambanis, A: Use of magnetic nanoparticles to monitor alginate-encapsulated btc-tet cells, Magn. Res, Med. 61(2):282-290, 2009.Sajja HK, East MP, Mao H, Wang YA, Nie S, Yang L. Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect. Curr Drug Discov Technol. 6:43-51, 2009.

2. Kaur, B, Cork, SM, Sandberg, EM, Devi, NS, Zhang, Z, Klenotic, PA, Febbraio, M, Shim, H, Mao, H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson, JJ, and Van Meir, EG: Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism, Cancer Research, 69(3):1212-20, 2009.

3. Yang L*, Mao, H*, Peng, XH, Cao, Z, Sajja HK, Wang L,Wang, AY, Wood, WC, and Nie, S: Molecular imaging of pancreatic cancer in a preclinical animal tumor model using targeted multifunctional nanoparticles, Gastroenterology, 136:1514-25, 2009. (* equal contribution).

4. Scheibel, RS, Newsome, MR, Troyanskaya, M, Steinberg, JL, Goldstein, FC, Mao, H and Levin, HS: Effects of severity of traumatic brain injury and brain reserve on cognitive-control related brain activation, J. Neuro. Trauma, 26:1447-61, 2009.

5. Wang L, Goldstein FG, Lah JJ, Meltzer CC, Levey A, Holder CA and Mao H*: Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole brain cortical thickness mapping and diffusion tensor imaging, AJNR, Amer. J. Neuroradiology, 30:893-9, 2009.

6. Goldstein, FC, Mao, H,Wang, L, Ni, C, Lah, JJ and Levey,AI, White matter integrity and episodic memory performance in mild cognitive impairment: a diffusion tensor imaging study. Brain Imaging and Behavior, 3: 132-141, 2009.

7. Yang L, Peng XH, Wang YA, Wang X, Cao Z, Ni C, Karna P, Zhang X, Wood WC, Gao X, Nie S, Mao H*. Receptor-targeted nanoparticles for in vivo imaging of breast cancer. Clin Cancer Res; 15:4722-32. 2009 (Featured on the Cover).

8. Liu, J, Cheng, EC, Long, R, Wang, L, Cheng, PH, Yang, JJ, Wu, D, Mao, H*. Chan, AWS. Noninvasive monitoring of embryonic stem cells in vivo with MRI transgene reporter, Tissue Engineering, 2009, 15(4):739-47.

9. Chen H, Wu, X, Duan, H, Wang, AY, Wang, L. Zhang, M & Mao, H*: Biocompatible polysiloxane-containing diblock copolymer PEO-b-PγMPS for coating magnetic nanoparticles; ACS Adv. Mat. & Interface, 2009, 1(10):2134-2140.

10. Guenther FH, Brumberg JS, Wright EJ, Nieto-Castanon A, Tourville JA, Panko M, Law R, Siebert SA, Bartels JL, Andreasen DS, Ehirim P, Mao H, Kennedy PR. A wireless brain-machine interface for real-time speech synthesis. PLoS One. 2009, 4(12):e8218.

11. Chen H, Wang L, Yeh J, Wu X, Cao Z, Wang YA, Zhang M, Yang L, Mao H*. Reducing non-specific binding and uptake of nanoparticles and improving cell targeting with an antifouling PEO-b-PgMPS copolymer coating. Biomaterials. 2010; 31(20):5397-407.

12. Wu X, Tan Y, Mao H and Zhang M. Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells International Journal of Nanomedicine 2010:5: 385–399.

13. Tzitzios V, Basina G, Bakandritsos A, Hadjipanayis CG, Mao H, Niarchos D, Hadjipanayis GC, Tucek J, Zboril R. Immobilization of magnetic iron oxide nanoparticles on laponite discs - an easy way to biocompatible ferrofluids and ferrogels. J Mater Chem. 2010; 20(26):5418-5428.

14. Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, Mao H, Hao C, Olson JJ, Curran WJ, Wang Y. Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One. 2010;5:e11397.

15. Hadjipanayis CG*, Machaidze R, Kaluzova, M, Wang, L, Schuette, AJ, Chen, H, Wu X and Mao, H*, EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced deliver and targeted therapy of glioblastoma. Cancer Res. 2010, 70: 6303-12.

16. Chen H, Yeh J, Wang L, Khurshid H, Peng N, Wang AW and Mao H*: Preparation and control of the formation of single core and clustered nanoparticles for biomedical applications using a versatile amphiphilic diblock copolymer, Nano Res. 2010, 3(12): 852-862.

17. Wei L, Li S, Yang J, Ye Y, Zou J, Wang L, Long R, Zurkiya O, Zhao T, Johnson J, Qiao J, Zhou W, Castiblanco A, Maor N, Chen Y, Mao H, Hu X, Yang JJ, Liu ZR.Protein-based MRI contrast agents for molecular imaging of prostate cancer.Mol Imaging Biol. 2010 (in press).

18. Abdalla MO, Karna P, Sajja HK, Mao H, Yates C, Turner T, Aneja R. Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapy, J Control Release. 2010 Nov 1 (in press).

19. Wang L, Goldstein FC, Levey AI, Lah JJ, Meltzer CC, Holder CA, Mao H*. White matter hyperintensities and changes in white matter integrity in patients with Alzheimer's disease.Neuroradiology. 2010 Dec 9. [Epub ahead of print]

20. Moreno-De-Luca A, Helmers SL, Mao H, Burns TG, Melton AM, Schmidt KR, Fernhoff PM, Ledbetter DH, Martin CL.Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability.J Med Genet.2011;48:141-144 doi:10.1136/jmg.2010.082263. (Editor’s Choice, Journal Cover)

21. Zhang L, Zhong X, Wang L, Chen H, Wang YA, Yeh J, Yang L, Mao H*.T₁-weighted ultrashort echo time method for positive contrast imaging of magnetic nanoparticles and cancer cells bound with the targeted nanoparticles.J Magn Reson Imaging. 2011; 33:194-202.

22. Qiao, J, Li, S, Wei, L, Jiang, J, Long, R, Mao, H, Ling, W, Wang, L, Grossniklaus, HE, Liu, ZR, Yang, JJ: HER2 Targeted Molecular MR Imaging Using a de novo Designed ProteinContrast Agent, PLoS One. 2011;(in press).

23. Wang, L, Chen, D, Olson, JJ, Ali, S, Fan, Tand Mao, H*: Tumor Induced Alterations in Hemodynamic Responses of BOLD fMRI: Implications in Presurgical Brain Mapping, Human Brain Mapping, 2011 (submitted).