Dr. Weizhen Zhang

Department of Surgery

Research Associate Professor

Department of Physiology

Peking University Health Science Center, China

Adjunct Professor

Email: weizhenz@umich.edu

Qualifications

1999-2000 Resident, Jackon Memorial Hospital, University of Miami, USA

1994-1995 Postdoctoral Fellow, University of Michigan School of Dentistry, USA

Publications(Selected)

1. Weizhen Zhang*, Michael W. Mulholland. Neuroplasticity in the dorsal vagal complex. In Andres Costa and Eugenio Villalba, ed.: Horizons in Neuroscience Research. Nova Science Publishers, Inc. Hauppauge, NY. 2009. pp341-354.
2. Weizhen Zhang* and Michael W. Mulholland. Calcium signaling in enteric glia of the enteric nervous system. In Andres Costa and Eugenio Villalba, ed.: Horizons in Neuroscience Research. Nova Science Publishers, Inc. Hauppauge, NY. 2009.pp257-272.
3. Xu G, An W, Li Y, Zhao J, Xiang X, Ding L, Li Z, Guan Y, Wang X, Tang C,Mulholland MW,Zhang W. Regulation of gastric hormone production by rapamycin. Peptides 2010;31:2185-92. PMID: 20804797.
4. Geyang Xu, Yin Li and Weizhen Zhang*. Gastric fuel sensing, ghrelin production and food intake. In Nejc S. Penkava and Logan R. Haight, ed.: Neuroendocrinology Research Developments. Nova Science Publishers, Inc. Hauppauge, NY. 2011.pp35-61.
5. Li J-Y, Chai B,Zhang W, Wu X, Zhang C, FritzeD, Xia Z, Patterson C and Mulholland MW. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation. BMC Neuroscience 2011; 12:95.
6. Xinxin Xiang, Jing Zhao, Yin Li and Weizhen Zhang*. Osteocalcin: from bone to vessel. In Masayoshi Yamaguchi, ed.: Osteocalcin: Production, Regulation and Disease. Nova Science Publishers, Inc. Hauppauge, NY. 2012. pp1-28.
7. Danielle M Fritze, Michael W. Mulholland, Weizhen Zhang*.Protease-Activated Receptor 2 in the Enteric Nervous System. In Kirk Weaver and Clayton Kelley, ed: Trypsin: Structure, Biosynthesis and Functions. Nova Science Publishers, Inc. Hauppauge, NY. 2012. pp117-131.
8. Xia Z, Fritze DM, Li J, Chai B, Zhang C,Zhang W*, Mulholland MW*. Nesfatin-1 inhibits gastric acid secretion via a central vagal mechanism in rats. Am J Physiol2012;303:G570-7.PMID:22723266
9. Amini P, Wadden D, Cahill F, Randell E, Vasdev S, Chen X, Gulliver W,Zhang W, Zhang H, Yi Y, Sun G. Serum Acylated Ghrelin is Negatively Correlated with the Insulin Resistance in the CODING study. PLoS one 2012;7:e45657. doi:10.1371
10. Xiang X, Yuan F, Zhao J, Li Z, Wang X, Guan Y, Tang C, Li Y,Zhang W. Deficiency in pulmonary surfactant proteins in mice with FABP4-cre mediated knockout of TSC1 gene. ExpPhysiol 2013;98:830-41.PMID:23143994
11. Tong Q, Duan L, Xu Z, Wang H, Wang X, Li Z,Zhang W, Zheng H.Improved insulin secretion following intrapancreatic UCB transplantation in patients with T2DM.J ClinEndocrinolMetab 2013;98(9):E1501-4. PMID:23861460
12. Li Z, Gao L, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M,Zhang W. Peripheral effects of nesfatin-1 on glucose homeostasis. PLoS one 2013;8(8): e71513. doi:10.1371/journal.pone.0071513
13. Zhang W*, Zhang C, Fritze D, Chai B, Li J, Mulholland M. Modulation of food intake by mTOR signaling in the dorsal motor nucleus of vagus in male rats: Focus on ghrelin and nesfatin-1. ExpPhysiol 2013;98(12):1696-704. PMID:23955309
14. Xiang X, An W, Jiang C, Zhao J, Wang X, Sun G, Li Y,Zhang W. Lipopolysaccharide inhibits the expression of resistin in adipocytes. J MolEndocrinol2013;51(3):287-99.PMID:23969982
15. Li JY, Chai B,Zhang W, Fritze DM, Zhang C, Mulholland MW.LGR4 and its ligands, R-spondin 1 and 3, regulate food intake in the hypothalamus of male rats.Endocrinology. 2014;155(2):429-40. PMID:24280058
16. Yin Y, Li Y,Zhang W. The Growth Hormone Secretagogue Receptor:Its Intracellular Signaling and Regulation.Int J MolSci 2014; 15: 4837-4855.
17. Qin Y, Li Z, Wang Z, Li Y, Zhao J, Mulholland M,Zhang W. Ghrelin contributes to protection of hepatocellular injury induced by ischemia-reperfusion. Liver Int 2014; 34(4):567-75. doi: 10.1111/liv.12286
18. Fritze D,Zhang W, Li J-Y, Chai B, Mulholland M. Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. J Gastrointest Surg. 2014;18(8):1495-506.
19. Fritze D,Zhang W, Li J-Y, Chai B, Mulholland M. TNFacauses thrombin-dependent vagal neuron apoptosis in inflammatory bowel disease. J Gastrointest Surg. 2014;18(9):1632-41. PMID:24961441
20. Li Z, Xu G, Qin Y, Zhang C, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M,Zhang W.Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARgsignaling pathway. ProcNatlAcadSci USA 2014; 111(36):13163-8.doi/10.1073/pnas.1411571111
21. Ding L, Han L, Li Y, Zhao J, He P,Zhang W.Neurogenin 3 directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma. Neoplasia 2014;16(11):909-17.
22. Xiang X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, Li Y,Zhang W. TSC1-mTOR signaling determines brown-to-white adipocyte phenotypic switch. Diabetes 2015;64(2):519-28. PMID:25213336
23. Xu Y, Li Z, Yin Y, Lan H, Wang J, Zhao J, Feng J, Li Y,Zhang W.Ghrelin inhibits the differentiation of T helper 17 cells through mTOR/STAT3 signaling pathway.PLoS One 2015;10(2):e0117081. doi:10.1371/journal.pone.0117081. PMID:25658305
24. Zhang W, Chang L, Zhang C, Zhang R, Li Z, Chai B, Li J, Chen E, Mulholland M. Central and peripheral irisin differentially regulate blood pressure. Cardiovasc Drugs Ther2015;29(2):121-7. PMID:25820670
25. Zhang W, Zhang C, Chang L, Zhang R, Li Z, Chai B, Li J, Chen E, Mulholland MW. Irisin: a myokine with locomotor activity.Neurosci Lett 2015;595:7-11.PMID:25841790
26. Xu G, Li Z, Tang H, Guo S, Wang H,Zhang W.Intestinal mTOR regulates GLP-1 production in L cells. Diabetologia2015; 58(8):1887-97. PMID:26037201.
27. Yin Y, Zhang W. The role of ghrelin in senescence. Gerontology 2015.PMID:26160147