Dr. Kamil Kuka

University of Defense, Czech Republic



2005 Ph.D., University of Defense

2001 M.Sc., Institute of Chemical Technology

Publications (selected)

  1. Kim T.H., Kuca K., Jun D, Jung Y.S.: Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators. Bioorganic Medicinal & Chemistry Letters. 2005, 15, 2914-2917.
  2. Kuca K., Jun D., Musilek K.: Structural requirements of acetylcholinesterase reactivators. Mini Reviews in Medicinal Chemistry. 2006, 6(3), 269-277.
  3. Musilek K.; Kuca K; Jun D.; Dolezal M.: Progress in synthesis of new acetylcholinesterase reactivators during the period 1990-2004. Current Organic Chemistry. 2007, 11(2), 229-238.
  4. Bajgar J., Fusek J., Kuca K., Bartosova L., Jun D.: Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction. Mini Reviews in Medicinal Chemistry. 2007, 7(5), 461-466
  5. Kuca K., Jun D., Bajgar J. Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications. Current Pharmaceutical Design. 2007, 13(33), 3445-3452.
  6. Musilek K., Holas O., Jun D., Dohnal V., Gunn-Moore F., Opletalova V., Dolezal M., Kuca K.: Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker – Preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase. Biorganic & Medicinal Chemistry. 2007; 15, 6733-6741.
  7. Musilek K., Jun D., Cabal J., Kassa J., Gunn-Moore F., Kuca K.: Design of a Potent Reactivator of Tabun-Inhibited Acetylcholinesterase - Synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203), Journal of Medicinal Chemistry. 2007, 50(22), 5514-5518.
  8. Patocka J., Jun D., Kuca K.: Possible Role of Hydroxylated Metabolites of Tacrine in Drug Toxicity and Therapy of Alzheimer´s Disease. Current Drug Metabolism. 2007, 9(4), 332-335.
  9. Kassa J., Karasova J., Musilek K., Kuca K.: An evaluation of therapeutic and reactivating effects of newly developed oximes  (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology. 2008, 243 (3), 311-316.
  10. Oh KA., Park NJ., Park NS., Kuca K., Jun D., Jung YS.: Determination of reactivation potency for DFP- and Paraoxon-Inhibited Acetylcholinesterases by Pyridinium Oximes. Chemico-Biological Interactions. 2008, 175(1-3), 365-367.
  11. Musilek K., Jampilek J., Dohnal J., Jun D., Gunn-Moore F., Dolezal M., Kuca K.: RP-HPLC lipophilicity determination of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker. Analytical & Bioanalytical Chemistry. 2008, 391(1), 367-372.
  12. Hamulakova S., Kristian P., Jun D., Kuca K., Imrich J., Danihel I., Bohm S., Klika KD. Synthesis, structure, and cholinergic efect of novel neuroprotective compounds bearing the tacrine pharmacophore. Heterocycles. 2008, 76(2), 1219-1235.
  13. Csermely T., Kalasz H., Petroianu G., Kuca K., Darvas F., Ludanyi K., Mudhafar AA., Tekes K.: Analysis of Pyridinium Aldoximes – A Chromatographic Approach. Current Medicinal Chemistry. 2008, 15(23), 2401-2418.
  14. Wu Q., Jezkova A., Yuan Z., Pavlikova L., Dohnal V., Kuca K. Biological degradation of aflatoxins. Drug Metabolisms Reviews 2009; 41, 1-7.
  15. Jeong HC., Park NJ., Chae CH., Musilek K., Kassa J., Kuca K., Jung YS. Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent. Bioorganic &Medicinal Chemistry. 2009, 17, 6213-7.
  16. Musilek K., Kucera J., Jun D., Dohnal V., Opletalova V., Kuca K.: Monoquaternary pyridinium salts with modified side chain– synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 2008, 16(17), 8218-8223.
  17. Bajgar J., Fusek J., Kassa J., Kuca K., Jun D.: Chemical Aspects of Pharmacological Prophylaxis Against Nerve Agent Poisoning. Current Medicinal Chemistry. 2009, 16(23), 2977-2986.
  18. Musilek K., Holas O., Misik J., Pohanka M., Novotny L., Dohnal V., Opletalova V., Kuca K. Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies. ChemMedChem. 2010, 5(2), 247-54.
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