Biography

Prof. Ben A. Bahr

Biotechnology Research and Training Center

University of North Carolina – Pembroke, USA

William C. Friday Chair and Professor of Molecular Biology and Biochemistry


Email: Bahr@uncp.edu


Qualifications

1989 Ph.D., University of California, USA, Chemistry

1984 B.A., University of California, USA, Molecular Biology and Biochemistry


Publications (selected)

  1. Almeida, M. F., Strangman, W., & Bahr, B. A. (2022). Distinct ginseng extracts produce disparate effects on proteostatic support through the autophagy‐lysosomal pathway that is linked to synaptic resilience and cognitive health. The FASEB Journal, 36.
  2. Almeida, M. F., Kinsey, S. A., & Bahr, B. A. (2022). Stimulation of autophagy and synaptic maintenance are commonalities induced by an exercise‐mimetic and diet supplement to avoid initiators of age‐related cognitive decline. The FASEB Journal, 36.
  3. Caba, E., Sherman, M. D., Farizatto, K. L., Alcira, B., Wang, H. W., Giardina, C., ... & Bahr, B. A. (2021). Excitotoxic stimulation activates distinct pathogenic and protective expression signatures in the hippocampus. Journal of Cellular and Molecular Medicine, 25(18), 9011-9027.
  4. Almeida, M. F., Piehler, T., Carstens, K. E., Zhao, M., Samadi, M., Dudek, S. M., ... & Bahr, B. A. (2021). Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures. Brain Pathology, 31(3), e12936.
  5. Telpoukhovskaia, M. A., Liu, K., Sayed, F. A., Etchegaray, J. I., Xie, M., Zhan, L., ... & Gan, L. (2020). Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Scientific reports, 10(1), 13688.
  6. Almeida, M. F., Bahr, B. A., & Kinsey, S. T. (2020). Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease. International review of neurobiology, 154, 303-324.
  7. Hwang, J., Estick, C. M., Ikonne, U. S., Butler, D., Pait, M. C., Elliott, L. H., ... & Bahr, B. A. (2019). The role of lysosomes in a broad disease-modifying approach evaluated across transgenic mouse models of Alzheimer’s disease and Parkinson’s disease and models of mild cognitive impairment. International journal of molecular sciences, 20(18), 4432.
  8. Lamani, M., Malamas, M. S., Farah, S. I., Shukla, V. G., Almeida, M. F., Weerts, C. M., ... & Makriyannis, A. (2019). Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & medicinal chemistry, 27(23), 115096.
  9. Kakoki, M., Bahnson, E. M., Hagaman, J. R., Siletzky, R. M., Grant, R., Kayashima, Y., ... & Maeda-Smithies, N. (2019). Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. JCI insight, 4(12).
  10. de Almeida, M. F., Pait, M., Rentschler, K., Farizatto, K. L., Norton, C., Tian, J., ... & Bahr, B. (2019). Plant Extracts Stimulate the Autophagy-lysosomal Protein Clearance Pathway and Improve Brain Synapse Markers in an Explant Model of Age-related Protein Accumulation Stress (FS05-04-19). Current Developments in Nutrition, 3, nzz052-FS05.
  11. Farizatto, K. L., Almeida, M. F., Long, R. T., & Bahr, B. A. (2019). Early synaptic alterations and selective adhesion signaling in hippocampal dendritic zones following organophosphate exposure. Scientific Reports, 9(1), 6532.
  12. Simões, A. P., Silva, C. G., Marques, J. M., Pochmann, D., Porciúncula, L. O., Ferreira, S., ... & Rodrigues, R. J. (2018). Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death & Disease, 9(3), 297.
  13. Piehler, T., Zander, N., Banton, R., Smith, M., Romine, H., Benjamin, R., ... & Bahr, B. A. (2018). Effects on neurons and hippocampal slices by single and multiple primary blast pressure waves from detonating spherical cyclotrimethylenetrinitramine (RDX) explosive charges. Military medicine, 183(suppl_1), 269-275.
  14. Piehler, T., Zander, N., Banton, R., Benjamin, R., Sparks, R., Byrnes, K., ... & Bahr, B. A. (2018). High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. In Dynamic Behavior of Materials, Volume 1: Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics (pp. 123-126). Springer International Publishing.
  15. Miquel, S., Champ, C., Day, J., Aarts, E., Bahr, B. A., Bakker, M., ... & Geurts, L. (2018). Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions. Ageing research reviews, 42, 40-55.
  16. Wang, C., Telpoukhovskaia, M. A., Bahr, B. A., Chen, X., & Gan, L. (2018). Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. Current opinion in neurobiology, 48, 52-58.
  17. Farizatto, K. L., McEwan, S. A., Naidoo, V., Nikas, S. P., Shukla, V. G., Almeida, M. F., ... & Bahr, B. A. (2017). Inhibitor of endocannabinoid deactivation protects against in vitro and in vivo neurotoxic effects of paraoxon. Journal of Molecular Neuroscience, 63, 115-122.
  18. Romine, H., Rentschler, K. M., Smith, K., Edwards, A., Colvin, C., Farizatto, K., ... & Bahr, B. A. (2017). Potential Alzheimer’s disease therapeutics among weak cysteine protease inhibitors exhibit mechanistic differences regarding extent of cathepsin B up-regulation and ability to block calpain. European scientific journal, 13, 38.
  19. Farizatto, K. L., Ikonne, U. S., Almeida, M. F., Ferrari, M. F., & Bahr, B. A. (2017). Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways. PLoS One, 12(8), e0182895.
  20. Parisian, C. M., Georgevitch, G., & Bahr, B. A. (2017). Military blast-induced synaptic changes with distinct vulnerability may explain behavioral alterations in the absence of obvious brain damage. Journal of nature and science, 3(7).
  21. Farizatto, K. L., & Bahr, B. A. (2017). Paraoxon: an anticholinesterase that triggers an excitotoxic cascade of oxidative stress, adhesion responses, and synaptic compromise. European scientific journal, 13, 29.
  22. Smith, M., Piehler, T., Benjamin, R., Farizatto, K. L., Pait, M. C., Almeida, M. F., ... & Bahr, B. A. (2016). Blast waves from detonated military explosive reduce GluR1 and synaptophysin levels in hippocampal slice cultures. Experimental neurology, 286, 107-115.
  23. Pait, M. C., Elliott, L., Hafner‐Ruiz, S., Mundell, C., Patterson, W., Romine, H., ... & Bahr, B. A. (2016). Development of Cathepsin B Positive Modulators to Treat Multi‐Proteinopathic Dementias: Exploiting the Lysosomal Avenue of Protein Clearance to Promote Synaptic Recovery. The FASEB Journal, 30, 707-1.
  24. Carrasco, D. I., Bahr, B. A., Seburn, K. L., & Pinter, M. J. (2016). Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease. Experimental neurology, 278, 116-126.
  25. Piehler, T., Banton, R., Piehler, L., Benjamin, R., Sparks, R., Smith, M., & Bahr, B. A. Preliminary Study of Realistic Blast Impact on Cultured Brain Slices.


Profile Details

https://scholar.google.com/citations?user=aQs1-2AAAAAJ&hl=en

https://www.uncp.edu/profile/ben-bahr

https://www.researchgate.net/profile/Ben-Bahr

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