Prof. David Vauzour

Faculty of Medicine and Health Sciences

University of East Anglia, UK

Research Fellow

Email: D.Vauzour@uea.ac.uk

Qualifications

2004 Ph.D., University of Montpellier, France, Chemical and Biological Sciences for Health

2001 M.Sc., University of Bordeaux, France, Biological and Medical Sciences

1999 B.Sc., University of Bordeaux, France, Molecular and Cellular Biochemistry/Pharmacology

Publications (selected)

1. Lang, L., Ditton, A., Stanescu, A., Jainani, V., McArthur, S., Pourtau, L., ... & Lazar, A. S. (2025). A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the Gut-Sleep-Brain Axis randomised, double-blind, placebo-controlled pilot study. medRxiv, 2025-02.
2. L’Heureux, J. E., Corbett, A., Ballard, C., Vauzour, D., Creese, B., Winyard, P. G., ... & Vanhatalo, A. (2025). Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype. PNAS nexus, 4(1), pgae543.
3. Kamarunzaman, N. N. Z., Le Sayec, M., Li, Y., Wu, H., Mesnage, R., Dalrymple, K., ... & Rodriguez-Mateos, A. (2024). Effects of cranberry (poly) phenols on mental health in university students: the CRANMOOD randomized controlled trial. Proceedings of the Nutrition Society, 83(OCE4), E279.
4. Shah, S. N., Knausenberger, T. B., Pontifex, M. G., Connell, E., Le Gall, G., Hardy, T. A., ... & McArthur, S. (2024). Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor. Gut Microbes, 16(1), 2431651.
5. Connell, E., Le Gall, G., McArthur, S., Lang, L., Breeze, B., Pontifex, M. G., ... & Vauzour, D. (2024). (Poly) phenol-rich grape and blueberry extract prevents LPS-induced disruption of the blood-brain barrier through the modulation of the gut microbiota-derived uremic toxins. Neurochemistry International, 180, 105878.
6. Breeze, B., Connell, E., Wileman, T., Muller, M., Vauzour, D., & Pontifex, M. G. (2024). Menopause and Alzheimer’s disease susceptibility: Exploring the potential mechanisms. Brain Research, 149170.
7. Mackenzie, G. G., Wirkus, J., Ead, A., Krga, I., Matsukuma, K., Muller, M., ... & Vauzour, D. (2024). The Impact of Fat Quantity and Composition in Pancreatic Carcinogenesis in Mice: Mitigating Obesity-Induced Tumor Progression With Dietary Changes. Current Developments in Nutrition, 8.
8. Beghelli, D., Giusti, L., Zallocco, L., Ronci, M., Cappelli, A., Pontifex, M. G., ... & Angeloni, C. (2024). Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversity. Food & Function, 15(14), 7468-7477.
9. Pontifex, M. G., Connell, E., Le Gall, G., Lang, L., Pourtau, L., Gaudout, D., ... & Vauzour, D. (2024). A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation. Gut Microbes, 16(1), 2363011.
10. Láng, L., McArthur, S., Lazar, A. S., Pourtau, L., Gaudout, D., Pontifex, M. G., ... & Vauzour, D. (2024). Dietary (Poly) phenols and the Gut–Brain Axis in Ageing. Nutrients, 16(10), 1500.
11. Connell, E., Sami, S., Khondoker, M., Minihane, A. M., Pontifex, M. G., Müller, M., ... & Vauzour, D. (2024). Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s disease. medRxiv, 2024-05.
12. Williams, Z. A., Lang, L., Nicolas, S., Clarke, G., Cryan, J., Vauzour, D., & Nolan, Y. M. (2024). Do microbes play a role in Alzheimer's disease?. Microbial Biotechnology, 17(4), e14462.
13. Connell, E., Blokker, B., Kellingray, L., Le Gall, G., Philo, M., Pontifex, M. G., ... & Vauzour, D. (2024). Refined diet consumption increases neuroinflammatory signalling through bile acid dysmetabolism. Nutritional Neuroscience, 27(10), 1088-1101.
14. Saleh, R., Hornberger, M., Pontifex, M., Vauzour, D., Ritchie, C., & Minihane, A. M. (2023). The effect of APOE?4 on neurocognitive decline is accentuated by female sex and menopause: Identification of mitigating interventions. Alzheimer's & Dementia, 19, e075413.
15. Hunt, T. J., Martinsen, A., Minihane, A. M., Flanagan, E., Hornberger, M., Mena, P., ... & Vauzour, D. (2023). Interactions between APOE Genotype, the Gut Microbiome and Polyphenol Metabolism. Alzheimer's & Dementia, 19, e079725.
16. Pontifex, M. G., Vauzour, D., & Muller, M. (2024). Sexual dimorphism in the context of nutrition and health. Proceedings of the Nutrition Society, 83(2), 109-119.
17. Coletto, E., Savva, G. M., Latousakis, D., Pontifex, M., Crost, E. H., Vaux, L., ... & Juge, N. (2023). Role of mucin glycosylation in the gut microbiota-brain axis of core 3 O-glycan deficient mice. Scientific Reports, 13(1), 13982.
18. Coxon, C., Hepsomali, P., Brandt, K., Vauzour, D., & Costabile, A. (2023). Personality, dietary identity, mental and sleep health in vegans and vegetarians: A preliminary cross‐sectional study. Health Science Reports, 6(8), e1525.
19. Vauzour, D., Scholey, A., White, D. J., Cohen, N. J., Cassidy, A., Gillings, R., ... & Minihane, A. M. (2023). A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study. The American journal of clinical nutrition, 118(2), 369-381.
20. Tosi, N., Favari, C., Bresciani, L., Flanagan, E., Hornberger, M., Narbad, A., ... & Mena, P. (2023). Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation. Food Research International, 172, 113187.
21. Martinsen, A., Saleh, R. N., Chouinard-Watkins, R., Bazinet, R., Harden, G., Dick, J., ... & Minihane, A. M. (2023). The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice. Nutrients, 15(9), 2032.
22. Angeloni, C., & Vauzour, D. (2023). Natural products and neuroprotection 3.0. International Journal of Molecular Sciences, 24(4), 3885.
23. Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., ... & Vauzour, D. (2022). Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia. Molecular neurodegeneration, 17(1), 43.
24. Shah, S. N., Knausenberger, T. B., Connell, E., Gall, G. L., Hardy, T. A., Randall, D. W., ... & McArthur, S. (2022). Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate is prevented by blockade of the epidermal growth factor receptor. bioRxiv, 2022-11.
25. Pontifex, M. G., Connell, E., Le Gall, G., Pourtau, L., Gaudout, D., Angeloni, C., ... & Vauzour, D. (2022). Saffron extract (Safr'Inside?) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites. Food & Function, 13(23), 12219-12233.

Profile Details

http://www.researcherid.com/rid/C-2245-2008

https://orcid.org/0000-0001-5952-8756

https://www.researchgate.net/profile/David-Vauzour