Dr. Deug Y. Shin

College of Medicine, Aging-Cancer Research Center

Dankook University, South Korea

Professor/Director

Email: dyshin@dankook.ac.kr

Qualifications

1989 Ph.D., The University of Tokyo, Molecular Biology & Genetics

1986 M.Sc., The University of Tokyo, Biochemistry & Genetics

1983 B.Sc., Busan National University, Microbiology

Publications

1. Kim, J. B., Kim, S. Y., Kim, B. M., Lee, H., Kim, I., Yun, J., Jo, Y., Oh, T., Chae, H. D., Shin, D. Y. (2013) Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. J. Biol. Chem., 288, 17, 12014-21.
2. Yun, U. J., Park, S. E., Jo, Y. S., Kim, J., Shin, D. Y. (2012) DNA damage induces the IL-6/STAT3 signaling pathway, which has anti-senescence and growth-promoting functions in human tumors. Cancer Letters, 323, 155-160.
3. Chae, H. D., Kim, B. M., Yun, U. J., Shin, D. Y. (2008) Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage. Oncogene, 27, 4115-4121.
4. Kang, S., Jung, M., Kim, C.W., Shin, D.Y.(2005), Inactivation of p38 kinase delays the onset of senescence in rabbit articuilar chondrocytes. Mech. Ageing. Devel. 126, 591-597.
5. Chae, H. D., Choi, T. S., Kim, B. M., Jung, J. H., Bang, Y. J., Shin, D. Y. (2005), Oocyte-based screening of cytokinesis inhibitors and identification of pectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors. Oncogene, 24, 4813-4819.
6. Jung, M. S., Jin, D. H., Chae, H. D., Kang, S., Kim, S. C., Bang, Y. J., Choi, T., Choi, K. S., Shin, D. Y. (2004), Bcl-xL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senescence by preventing reactive oxygen species-dependent p38 activation. J. Biol. Chem., 279, 17765-71.
7. Yun, J., Chae, H. D., Choi, T. S., Kim, E. H., Bang, Y. J., Chung, J., Choi, K. S., Mantovani, R., Shin, D. Y. (2003), Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway, J. Biol. Chem., 278, 36966-72.
8. Jung, M. S., Yun, J., Chae, H. D., Kim, J. M., Kim, S. C., Choi, T. S., Shin, D. Y. (2001), p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene, 20, 5818-25.
9. Park, M., Chae, H. D., Yun, J., Jung, M., Kim, Y.S., Kim, S. H., Han, M. H., Shin, D. Y. (2000), Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Can. Res. 60, 542-545.
10. Yun, J., Chae, H. D., Choy, H. E., Chung, J., Yoo, H. S., Han, M. H., Shin, D. Y. (1999), p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. J. Biol. Chem., 274, 29677-82.
11. Shin, D. Y., Sugrue, M. M., Lee, S. W., Aaronson, S. A. (1997), Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc. Natl. Aca. Sci. USA, 94, 9648.

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