Biography

Dr. Tai-huang Huang

Institute of Biomedical Sciences

Academia Sinica, Taiwan

Distinguished Research Fellow


Email: taihuanghuang@gmail.com, bmthh@ibms.sinica.edu.tw


Qualifications


1979 Ph.D., Brandeis University, Physics

1969 M.Sc., M.I.T., Nat'l Magnet Lab


Publications (Selected)

  1. Huang, S.Y., Chang, C.F., Fang, P.J., Naik, M.T., Güntert, P. Shih, H.M., and Huang, T.-h.* (2015) “NMR structure note: The RING domain of human promyelocytic leukemia protein (PML)” J. Biomol. NMR (2015) 61 (2), 173-180.
  2. Huang, S.Y., Naik, M.T., Chang, C.F., Fang, P.J., Wang, Y.H., Shih, H.M., and Huang, T.-h.* “NMR structure note: The B-box 1 dimer of human promyelocytic leukemia protein” J. Biomol. NMR,, (2014) 60, 275-281.
  3. Chang, C.K., Hou, M. H., Chang, C.F., Hsiao, C.D. and Huang, T.-h.* (2014) “The SARS Coronavirus Nucleocapsid Protein – Forms and Functions” Antiviral Res. 103:39-50.
  4. Kung, C.C.H., Nail, M.T., Wang, S.H. Shih, H.M. Chang, C.C., Lin, L.Y. Chen, Ma, C., Chang, C.-F. and Huang, .T.-h.* (2014) “Structural Analysis of Poly-SUMO Chain Recognition by RNF4-SIMs Domain” Biochem. J. 462(1):53-65.
  5. Li, Y.-C., Chang, C.-K., Chang, C.F., Cheng, Y.H., Fang, P.R., Yu, T., Chen, S.C., Hsiao, C.D.* and Huang, T.-h.* (2014) “Structural dynamics of two-component response regulator RstA from Klebsiella pneumoniae in recognition of promoter DNA element”. Nucleic Acid Res. 42 (13), 8777-8788
  6. Hsueh, K.L. Yu, L.K., Chen, Y.H., Cheng, Y.H., Hsieh, Y.C., Ke, S.C., Hung, K.W., Chen, C.J. and Huang, T.-h.* (2013) “FeoC from Klebsiella pneumoniae contains a [4Fe-4S] cluster” J. Bacteriol. 195(20): 4726-4734.
  7. Lo, Y.S., Lin, S.Y., Wang, S.M., Wang, C.T., Chiu, Y.L., Huang, T.-h. and Hou, M.H.* (2013) “Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid” FEBS Lett. 587 (2), 120-127
  8. Hsieh, Y.L., Kuo, H.Y., Naik, M.T., Chang, C.C., Liao, P.H., Ho, C.C., Huang, T.C., Jeng, J.C., Hsu, P.H., Tsai, M.D., Huang, T.-h. and Shih, S.H.* (2013) “Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response”. EMBO J. 32, 791-804.
  9. Chang, C.K., Chiang, M.H., Toh, E.K.-W., Chang, C.F. and Huang, T.-h.* (2013) “Molecular mechanism of oxidation-induced trans-activating response region DNA-binding protein of 43 kDa (TDP-43) aggregation and loss of function” FEBS Lett. 587 (6), 575-582
  10. Chen, I.J., Yuann, J.M., Chang, Y.M., Lin, S.Y., Zhao, Perlman, S., Shen, Y.Y., Huang, T.-h.; Hou, M.H.* (2013) “Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain” of human coronavirus OC43 nucleocapsid protein” Biochimica et Biophysica Acta – Proteins and Proteomics 1834(6): 1054-1062.
  11. Chang, C.K., Chen, C.M., Chiang, M.H.. Hsu, Y.L., Chang, C.F. and Huang., T.-h.*  (2013) “Transient Oligomerization of the SARS-CoV N Protein – Implication for virus ribonucleoprotein packaging”, PLoS ONE 8 (5) e65045, doi: 10.1371/journal.pone.0065045.
  12. Hung, K.W., Tsai, J.Y., Juan, T.H., Hsu, Y.L., Hsiao, C.D.* and Huang, T.H.* (2012) “Crystal structure of KpNFeoB/KpFeoC complex and the roles of FeoC in the regulation of Fe2+ transport by the bacterial Feo system”. J. Bacteriology, 194(23), 6518-26.
  13. Chou, C,-Y. Chu, M. Chang, C.-F. Huang, T.-h.* (2012) “A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR” J. Magn. Resonance 214(1), 302-308).
  14. Sekiyama, N., Jee, J., Isogai, S., Akagi, K.I., Huang, T.-h., Ariyoshi, M., Tochio, H. and Shirakawa, M.* (2012) “NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80.” J Biomol NMR. 52(4), 339-350.
  15. Hung, K.W., Juan, T.H., Hsu, Y.L. and Huang, T.-h.* (2012) “NMR structure note: The ferrous iron transport protein C (FeoC) from Klebsiella pneumoniae” J. Biomol. NMR 53 (2) 161-165.
  16. Chang, C.K., Wu, T.H., Wu, C.Y., Chiang, M.H., Toh, E.K.W., Hsu, Y.C., Lin, K.F., Liao, Y.H., Huang, T.-h*., Huang, J.J.T.* (2012) “The effect of the N-terminus on the oligomerization process and DNA binding affinity of TDP-43” Biochem. Biophys. Res. Comm. 425 (2), 219-224.
  17. Wang, C.H., Davamani, F., Sue, S.C., Lee, S.C., Wu, P.L.., Tang, F.M., Shih, C., Huang, T.-h.* and Wu*, W.G. (2011) “Cell surface heparan sulfates mediate internalization of PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signaling process involved in fibroblast cell migration”,  Biochem. J. 433(1), 127-138.
  18. Chang, C.C., Naik, M.T., Huang, Y.S., Jeng, J.C., Liao, P.H., Kuo, H.Y., Ho, C.C., Hsieh, Y.L., Lin, C.H., Huang, N.J., Naik, N.M., Kung, C.C.H., Lin, S.Y., Chen, R.H., Chang, K.S., Huang, T.-h.*, and Shih, H.M.* (April, 2011) “Structural and functional roles of Daxx SIM phosphorylation in SUMO paralogue-selective binding and apoptosis modulation” Mol. Cell, 42(1), 62-74.
  19. Brautigam*, C. A. Wynn, R. M., Chuang, J. L., Naik3, M.T., Young, B.B., Huang, T.-h. and Chuang, D.T.* (2011) “Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex” J. Biol. Chem. 286(26): 23476- 23488
  20. Jiang, I., Tsai, C.-K., Chen, S.C., Wang, S., Amiraslanov, I., Chang, C.F., Wu, W.J., Tai, J.H., Liaw, Y.C.* and Huang, T.-h*. (2011) “Molecular basis of the recognition of the ap65-1 gene transcription promoter elements by a Myb protein from the protozoan parasite Trichomonas vaginalis” Nucleic Acid Res. 39(20), 8992-9008.
  21. Hung, K.W., Chang, Y.W., Eng, E.T., Chen, J.H., Chen, Y.C., Sun, Y.J., Hsiao, C.D.*, Dong, G., Spasov, K.A., Unger, V.M., & Huang, T.-h.* (Jun, 2010) “Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB” J. Struct. Biol. 170(3), 501-512
  22. Fang, H. J., Chen, Y. Z., Li, M. S.*, Wu, M. C.*, Chang, C. L., Chang, C. K., Hsu, Y. L., Huang, T. -h.*, Chen, H. M., Tsong, T. Y.*, Hu, C. K.* (2009) “Thermostability of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid protein: Experiments and numerical simulations” Biophys. J. 96(5):1892-901.
  23. Chang, C.K., Hsu, Y.L., Chang, Y.H., Chao, F.A., Wu, M.C., Huang, Y.S., Hu, C.K., Huang, T.-h.* (2009) “Multiple Nucleic Acid Binding Sites and Intrinsic Disorder of Severe Acute Respiratory Syndrom Coronavirus Nucleocapsid Protein: Implication for Ribonucleocapsid Protein Packaging”, J. Virol. 83: 2255-2264
  24. Naik, M.T., Chang, C.F., Kuo, I.C., Kung, C.C.H., Chua, K.Y.* and Huang, T.-h.* (2008) “Roles of structure and structural dynamics in the antibody recognitio04n of the allergen proteins: A NMR study on Blomia tropicalis major allergen” Structure 16, 125-136.
  25. Takeda, M., Chang, C.K., Ikeya, T. Güntert, P., Chang, Y.S., Hsu, Y.L., Huang, T.-h.*, and Kainosho, M.* (2008) “Solution Structure of the C-terminal Dimerization Domain of SARS Coronavirus Nucleocapsid Protein Solved by the SAIL-NMR Method” J. Mol. Biol. 380, 608-622.



Personal Website: http://www.ibms.sinica.edu.tw/pages/pi/index.php?id=33

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