Dr. Cai Lu

University of Louisville, USA

Email: L0cai001@louisville.edu

Qualifications

1990 Ph.D., Norman Bethune University of Medical Sciences, China

1986 M.Sc., Norman Bethune University of Medical Sciences, China

1983 B.Sc., Norman Bethune University of Medical Sciences, China

Publications (selected)

1. He XQ, Kan H, Cai L#, Ma Q. Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes. J Mol Cell Cardiol, 46: 47-58, 2009.
2. Liu QJ, Sun L, Tan Y, Wang G, Lin X, Cai L*. Role of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications. Currents in Medicinal Chemistry, 16: 113-129, 2009.
3. Huang Y, Su Z, Su Y, Ding C, Zhang M, Feng C, Tan Y, Feng W, Li XK, Cai L*. Expression and purification of GST-SUMO-MT fusion protein, and its neuronal and hepatic protection against D-galactose-induced oxidative damage in mouse model. J Pharmcol Exp Ther. 329: 469-78, 2009.
4. Xue W, Liu Q, Cai L, Wang Z, Feng W. Stable overexpression of human metallothionein-IIA in a heart derived cell line confers oxidative protection. Toxicology Letters, 188: 70-76, 2009.
5. Tan Y, Li Y, Xiao J, Shao HW, Ding C, Arteel GE, Yan J, Yu H, Cai L#, Li XK. A novel CXCR4 antagonist derived from human SDF-1β enhances angiogenesis in ischemic mice. Cardiovascular Research, 82: 513-521, 2009.
6. Guo KK, Ceylan-Isik AF, Carlson EC, Privratsky JR, Liao SJ, Cai L, Chen AF, Ren J. Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defect: Role of mitochondrial biogenesis. Hypertension, 53: 1023-1031, 2009. Which was accompanied with a commentary by J Bauersachs and JD. Widder. Endothelial Nitric Oxide Synthase, and Mitochondrial Function in the Heart. Hypertension 53:907-908, 2009.
7. Wang Y, Feng W, Xue WL, Tan Y, Hein DW, Li XK, Cai L*. Inactivation of GSK-3β by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, oxidative damage and remodelling. Diabetes, 58:1391–1402, 2009.
8. Xi S, Zhou G, Zhang X, Zhang W, Cai L#, Zhao C. Protection of total aralosides of aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. Exp Mol Med. 41: 538-547, 2009.
9. Xu J, Wang GJ, Wang Y, Liu QJ, Tan Y, Cai L*. Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death: Metallothionein protection. Journal of Cellular and Molecular Medicine, 13: 1499 – 1512, 2009.
10. Wei W, Liu QJ, Liu LC, Tan Y, Li XK, Cai L*. Oxidative stress, diabetes, and diabetic complications. Hemoglubin 33: 370-377, 2009.
11. Liu QJ, Wang GJ, Zhou GH, Tan Y, Wang XL, Wei W, Liu LC, Feng WK, Cai L*. Angiotensin II induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein. Toxicology Letters, 191: 314-320, 2009.
12. Zhang C, Tan Y, Guo WY, Li C, Ji SZ, Li XK, Cai L*. Attenuation of diabetic renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. Am J Physiol Endocrinol Metab, 297: E1366-1377, 2009.
13. Lin SQ, Xu HW, Xiao J, Liu YL, Zhang Y, Cai L, Li XK, Tan Y. Combined use of acid fibroblast growth factor, granulocyte colony-stimulating factor and zinc sulphate accelerates diabetic ulcer healing. Journal of Health Science, 55: 910-922, 2009.
14. Rane MJ, Song Y, Ji SY, Barati M, Wu R, Amanullah H, Wang, Y, Tan Y, Zhou G, Klein JB, Li XK, Cai L#. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol. 298: F49-61, 2010.
15. Zhang C, Su Z, Zhao B, Qu Q, Tan Y, Cai L#, Li XK. Tat-modified leptin is more accessible to hypothalamus through brain-blood barrier with a significant inhibition of body-weigh gain in high-fat-diet fed mice. Experimental and Clinical Endocrinology & Diabetes, 118: 31-37, 2010.
16. Lin SQ, Xu HW, Xiao J, Liu YL, Zhang Y, Cai L, Li XK, Tan Y. Combined use of acid fibroblast growth factor, granulocyte colony-stimulating factor and zinc sulphate accelerates diabetic ulcer healing. Journal of Health Science, 55: 910-922, 2009.
17. Rane MJ, Song Y, Ji SY, Barati M, Wu R, Amanullah H, Wang, Y, Tan Y, Zhou G, Klein JB, Li XK, Cai L#. Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol. 298: F49-61, 2010.
18. Zhang C, Su Z, Zhao B, Qu Q, Tan Y, Cai L#, Li XK. Tat-modified leptin is more accessible to hypothalamus through brain-blood barrier with a significant inhibition of body-weigh gain in high-fat-diet fed mice. Experimental and Clinical Endocrinology & Diabetes, 118: 31-37, 2010.
19. Guo WY, Wang GJ, Wang P, Chen Q, Cai L*. Low-Dose Radiation Accelerates Diabetic Wound Healing Most Likely through Peripheral Mobilization of Bone Marrow Stem Cells. Radiat Res. Under revision.
20. Xue WL, Cai L#, Tan Y, Thistlethwaite P, Kang YJ, Feng W. Cardiac-specific overexpression of hypoxia-inducible factor 1α protects myocardial injury in diabetic mice. Am J Pathol. Under revision
21. Zhang C, Jin SZ, Guo WY, Li C, Li XK, Cai L*. Effects of Low-Dose Radiation on Cardiac damage and Cardiovascular Inflammation. Radiat Res. Under revision.