Dr. Lisa M. Minter

Department of Veterinary & Animal Sciences

University of Massachusetts/Amherst, USA

Associate Professor

Email: lminter@vasci.umass.edu

Qualifications

2015-Present Associate Professor, Department of Veterinary & Animal Sciences, University of Massachusetts/Amherst

2009-2015 Assistant Professor, Department of Veterinary & Animal Sciences, University of Massachusetts/Amherst

2001-2004 Post-doctoral Fellow, University of Massachusetts/Amherst, Cellular & Molecular Immunology

2001 Ph.D., University of Massachusetts/Amherst, Animal Biotechnology & Biomedical Sciences

1981 B.Sc., Catholic University of America, Medical Technology

Selected Publications

1. C Arieta Kuksin, Gonzalez Perez G, and LM Minter (2015). CXCR4 expression on pathogenic T cells facilitates their bone marrow-infiltration in a mouse model of aplastic anemia. Blood 125:2087-2094. [IF = 9.77]
2. Shin HM, ME Tilahun, OH Cho, K Chandiran, CA Kuksin, S Keerthivasan, AH Fauq, TE Golde, L Miele, M Thome, BA Osborne, and LM Minter (2014) NOTCH1 Can Initiate NF-B Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Frontiers in Immunology 5:249-263.
3. Sgolastra F, LM Minter, BA Osborne, and GN Tew (2014) Importance of sequence specific hydrophobicity in synthetic protein transduction domain mimics. Biomacromolecules 15:812-20 [IF = 5.371]
4. Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, and BA Osborne (2014) Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. Frontiers in Immunology 5:54-67.
5. Roderick J. E., Gonzalez-Perez G., Kuksin C. A., Dongre A., Roberts E. R., Srinivasan J., Andrzejewski C., Fauq A. H., Golde T. E., Miele L., Minter L. M. (2013), Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med. 210, 1311-1329.
6. Tezgel A. Ö., Gonzalez-Perez G., Telfer J. C., Osborne B. A., Minter L. M., Tew G. N. (2013) Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells. Mol Ther. 21, 201-209.
7. Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne B. A., Golde T. E. (2012), Transient pharmacologic lowering of Aß production prior to deposition results in sustained reduction of amyloid plaque pathology. Mol Neurodegener. 7, 39.
8. Minter L. M., Osborne B. A. (2012), Notch and the survival of regulatory T cells: location is everything! Sci Signal. 5, 234, pe31.
9. Palaga T, Minter L. M. (2012) Notch signaling and its emerging role in autoimmunity. Front Biol, DOI: 10.1007/s11515-012-1209-z.
10. Minter L. M., Osborne B. A. (2012) Canonical and Non-Canonical Notch Signaling in CD4 (+) T Cells. Curr Top Microbiol Immunol, 360, 99-114.
11. Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff B. J., Le Poole I. C., Miele L, Osborne B. A. (2011), Notch signaling regulates mouse and human Th17 differentiation. J Immunol. 187, 692-701.
12. Cho O. H., Shin H. M., Miele L, Golde T. E., Fauq A, Minter L. M., Osborne B. A. (2009), Notch regulates cytolytic effector function in CD8+ T cells. J Immunol. 182, 3380-3389.
13. Joshi I, Minter L. M., Telfer J, Demarest R. M., Capobianco A. J., Aster J. C., Sicinski P, Fauq A, Golde T. E., Osborne B. A. (2009), Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 113, 1689-98.
14. Samon J. B., Champhekar A, Minter L. M., Telfer J. C., Miele L, Fauq A, Das P, Golde T. E., Osborne B. A. (2008), Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood. 112, 1813-1821.
15. Osborne B. A., Minter L. M. (2007), Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol. 7, 64-75.
16. Shin H. M., Minter L. M., Cho O. H., Gottipati S, Fauq A. H., Golde T. E., Sonenshein G. E., Osborne B. A. (2006), Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J. 25, 129-138.
17. Minter L. M., Turley D. M., Das P, Shin H. M., Joshi I, Lawlor R. G., Cho O. H., Palaga T, Gottipati S, Telfer J. C., Kostura L, Fauq A. H., Simpson K, Such K. A., Miele L, Golde T. E., Miller S. D., Osborne B. A. (2005), Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol. 6, 680-688.

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