Biography

Dr. Wing Cheong Yam
Department of Microbiology

The University of Hong Kong, China
Clinical bacteriologist / Honorary Associate Professor


Email: wcyam@hkucc.hku.hk


Qualifications
2010 Founding Fellow member, Faculty of Science, Royal College of Pathologists, Australasia
2008 Fellow member of Royal College of Pathologists, United Kingdom

2005 Member of Royal College of Pathologists, United Kingdom
1994 Fellow member of Institute of Biomedical Sciences, United Kingdom
1989 Chartered member of the Institute of Biology, United Kingdom


Publications (Selected)

  1. To KK, Hung IF, Xu T, Poon RW, Ip WC, Li PT, Li CP, Lau SK,Yam WC, Chan KH, Yuen KY. Clinical significance of Pneumocystis jiroveci in patients with activetuberculosis. Diagn Microbiol Infect Dis. 2013 Mar;75(3):260-5.
  2. Dheda K, Ruhwald M, Theron G, Peter J, Yam WC.Point-of-care diagnosis of tuberculosis: past, present and future. Respirology. 2013 Feb; 18(2): 217-32.
  3. Yam WC, Siu KH. Rapid identification of mycobacteria and rapid detection of drug resistance in Mycobacterium tuberculosis in cultured isolates and in respiratory specimens. Methods Mol Biol. 2013; c943: 171-99.
  4. Zhu C, Zhang Y, Shen Y, Siu GK, Wu W, Qian X, Deng G, Xu Y, Lau R, Fan X, Zhang W, Lu H, Yam WC.Molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosisclinical isolates from Shanghai, China. Diagn Microbiol Infect Dis. 2012 Jul; 73(3): 260-3.
  5. Lee AS, Ong DC, Wong JC, Siu GK, Yam WC.High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacteriumtuberculosis. PLoS One. 2012;7(2):e31934.
  6. Lau W T, Ho PL, Kao YT, WW Yew, CK Lau, VCC Cheng, KYYuen, KW Tsui, XC Chen, and WC Yam. Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis ofgyrA Mutantat Position 74. 2010 Antimicrobial Agents and Chemotherapy. 2011, 55 (2) 608-614.
  7. J.T. Lam, K.Y. Yuen, P.L. Ho, X.H. Weng, W.H. Zhang, S. Chen, W.C. Yam*Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo.Microbial Pathogenesis. 2011(50) 331-335.
  8. Gilman Kit Hang Siu, Ying Zhang, Terrence C. K. Lau, Ricky W. T. Lau, Pak-Leung Ho, Wing-Wai Yew,Stephen K. W. Tsui, Vincent C. C. Cheng, Kwok-Yung Yuen andW.C.Yam*Mutations outside the rifampicin resistance-determining regionassociated with rifampicin resistance in Mycobacterium tuberculosis. J Antimicrobial Chemotherapy. 2011, 66 (4) 730-733.
  9. SiuGKH, YHTam, PLHo, ASKLee,TQQue, CWSTse, KTYip, JTHLam, VCC Cheng, KY Yuenand WC Yam. Direct detection of isoniazid-resistant Mycobacterium tuberculosisi nrespiratory specimens by multiplex allele-specific PCR 2010 Diagn Microbiol Infect Dis. 2011 (69) 51-58.
  10. Leung CC, Yam WC, Yew WW, Ho PL, Tam CM, Law WS, Au KF, Tsui PW. T-Spot. TB outperforms tuberculin skin test in predicting tuberculosis disease. Am J Respir Crit Care Med.2010 Sep 15; 182(6): 834-40.
  11. Ong DC,Yam WC, Siu GK, Lee AS. Rapid Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis by High-Resolution Melting Analysis. J Clin Microbiol. 2010 Feb 17.
  12. Lau RW, Ho PL, Kao RY, Siu GK, Cheng VC, Yuen KY,Yam WC. Rapid diagnosis of multidrug-resistant smear-positive pulmonary tuberculosis. Int J Antimicrob Agents. 2010 Feb; 35(2): 202-3.
  13. Leung CC, Yam WC, Yew WW, Ho PL, Tam CM, Law WS, Wong MY, Leung M, Tsui D.Comparison of T-Spot. TB and tuberculin skin test among silicotic patients. Eur Respir J. 2008 Feb; 31(2): 266-72.
  14. Lam TH, Yuen KY, Ho PL, Wong KC, Leong WM, Law HK, Weng XH, Zhang WH, Chen S,Yam WC*.Differential fadE28 expression associated with phenotypic virulence of Mycobacterium tuberculosis. Microb Pathog. 2008 Jul; 45(1): 12-7.
  15. Leung KH, Yip SP, Wong WS, Yiu LS, Chan KK, Lai WM, Chow EY, Lin CK,Yam WC,Chan KS.Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study. BMC Infect Dis. 2007 Mar 19; 7:19.
  16. Tam WO, Yew WW,Yam WC, Yuen KY, Wong PC, Tse TF. Pacemaker infections due to rapidly growing mycobacteria: further experience. Int J Tuberc Lung Dis.2007 Jan; 11(1): 118.
  17. Wong KC, Leong WM, Law HK, Ip KF, Lam JT, Yuen KY, Ho PL, Tse WS, Weng XH, Zhang WH, Chen S,Yam WC*. Molecular characterization of clinical isolates of Mycobacterium tuberculosis and their association with phenotypic virulence in human macrophages. Clin Vaccine Immunol.2007 Oct; 14(10): 1279-84.
  18. Leung, E.T.Y., Ho, P.L., Yuen, K.Y., Woo, W.L., Lam, T.H., Kao, R.Y., Seto, W.H.,Yam, W.C*. Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: Identification of a novel mutation in inhA (2006) Antimicrobial Agents and Chemotherapy, 50 (3), pp. 1075-1078.
  19. Yam WC, Yuen KY, Kam SY, Yiu LS, Chan KS, Leung CC, Tam CM, Ho PO, Yew WW, Seto WH, Ho PL.Diagnostic application of genotypic identification of mycobacteria. J Med Microbiol. 2006 May; 55(Pt 5): 529-36.
  20. Yam WC, CM Tam, CC Leung, HL Tong, KH Chan, ETY Leung, KC Wong, WW Yew, WH Seto, KY Yuen, and PL Ho. Direct Detection of Rifampin-ResistantMycobacterium tuberculosisin Respiratory Specimens by PCR-DNA sequencing. J Clin Microbiol 2004 42: 4438-4443.
  21. Yam WC, V.C.C. Cheng, W.T. Hui, L.N. Wang, W.H. Seto, K.Y. Yuen. Direct Detection of Mycobacterium tuberculosisin Clinical Specimens using Single-Tube biotinylated Nested PCR-ELISA Diagn Microbiol Infect Dis. 2004 48: 271-275.
  22. Cheng VC,Yam WC, Hung IF, Woo PC, Lau SK, Tang BS, Yuen KY. Clinical evaluation of the polymerase chain reaction for the rapid diagnosis of tuberculosis. J Clin Pathol. 2004 Mar; 57(3): 281-5.
  23. Leung ET, Kam KM, Chiu A, Ho PL, Seto WH, Yuen KY,Yam WC*.Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP. J Med Microbiol. 2003 Nov; 52(11): 999-1003.
  24. Cheng VC,Yam WC, Woo PC, Lau SK, Hung IF, Wong SP, Cheung WC, Yuen KY.Risk factors for development of paradoxical response during antituberculosis therapy in HIV-negative patients. Eur J Clin Microbiol Infect Dis. 2003 Oct; 22(10): 597-602.
  25. Yam WC, Yuen KY, Seto WH. Direct detection of Mycobacterium tuberculosis in respiratory specimens using an automated DNA amplification assay and a single tube nested polymerase chain reaction (PCR). Clin Chem Lab Med. 1998 Aug; 36(8): 597-9.


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