Prof. Changbin Shi

Department of Neurosurgery

Harbin Medical University, China


Department of Surgery

The University of Chicago, USA

Assistant Professor



2002-2006 Ph.D., Lund University, Sweden, Surgery and Hematopoietic Stem Cell Biology

2001-2002 Senior Visiting Scholar, Kansai Medical University, Japan, Neurosurgery and Microbiology

1998-2000 M.Sc., Harbin Medical University, China, Neurosurgery

1981-1986 M.D. & B.S., Harbin Medical University, China

Publications (Selected)

  1. Shi C, Zhao X, Lagergren A, Sigvardsson M, Wang XD, Andersson R. 2006. Immune status and inflammatory response differ locally and systemically in severe acute pancreatitis. Scand J Gastroenterol 41: 472-480.
  2. Zhao X, Shi C, Wang XD, Andersson R. 2006. Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis. Respir Physiol Neurobiol 152: 16-26.
  3. Shi C, Zhao X, Wang XD, Zhao L, Andersson R. 2007. Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats. Vascul Pharmacol 46: 406-411.
  4. Shi C, Shenkar R, Batjer HH, Check IJ, Awad IA. 2007. Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation. J Neurosurg 107: 1023-1026.
  5. Shenkar R, Venkatasubramanian PN, Wyrwicz AM, Zhao J, Shi C, Akers A, Marchuk DA, Awad IA. 2008. Advanced magnetic resonance imaging of cerebral cavernous malformations: Part II. Imaging of lesions in murine models. Neurosurgery 63:790-797.
  6. Shi C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, Shenkar R, Getch CC, Bredel M, Batjer HH, Bendok BR. 2009. Genomics of human intracranial aneurysm wall. Stroke 40: 1252-61.
  7. Shi C, Shenkar R, Du H, Duckworth E, Raja H, Batjer HH, Awad IA. 2009. Immune response in human cerebral cavernous malformations. Stroke 40: 1659-65.
  8. Zheng B, Zheng T, Wang L, Chen X, Shi C*, Zhao S. 2010. Aminoguanidine inhibition of iNOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in rabbits via restoration of dysfunctional endothelial cells. J Neurol Sci. 295: 97-103. [*co-corresponding author]
  9. Zheng B, Qiu Y, Jin H, Wang L, Chen X, Shi C*, Zhao S. 2011. A predictive value of hyponatremia for poor outcome and cerebral infarction in high-grade aneurysmal  subarachnoid  hemorrhage patients. J Neurol Neurosurg Psychiatry 82: 213-7. [*co-corresponding author]
  10. Liu Y, Zhang X, Liang Y, Yu H, Chen X, Zheng T, Zheng B, Wang L, Zhao L, Shi C, Zhao S. 2011. Targeting XBP1 Enhances Sensitivity of Glioma Cells to Oxidative Stress. Neuropathol Appl Neurobiol 37: 395-405.
  11. McDonald DA, Shenkar R*, Shi C*, Stockton RA, Akers AL, Kucherlapat MH, Kucherlapati R, Brainer J, Ginsberg MH, Awad IA, and Marchuk DA. 2011. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet 20: 211-22. [*co-2nd author]
  12. Liu Y, Liang Y, Zheng T, Yang G, Zhang X, Sun Z, Shi C, Zhao S. 2011. Inhibition of heme oxygenase-1 enhances anti-cancer effects of arsenic trioxide on glioma cells. J Neurooncol 104: 449-58.
  13. Yang G, Zhang R, Chen X, Mu Y, Ai J, Shi C, Liu Y, Shi C, Sun L, Rainov NG, Li H, Yang B, Zhao S. 2011. MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status. J Mol Med (Berl) 89: 1037-50.
  14. McDonald DA*, Shi C*, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. 2012. Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease. Stroke. 43: 571-4. [*co-1st author]
  15. Zhao S, Chen X, Wang L, Yang G, Han D, Teng L, Yang M, Wang D, Shi C, Liu Y, Zheng B, Shi C, Gao X, Rainov NG. 2013. Increased Expression of ABCB6 Enhances Protoporphyrin IX Accumulation and Photodynamic Effect in Human Glioma. Ann Surg Oncol. 20: 4379-88.
  16. Zhao S, Yang G, Mu Y, Han D, Shi C, Chen X, Zhang D, Deng Y, Wang L, Liu Y, Hou X, Wang C, Wu J, Wang L, Liu H, Zhang G, Qi J, Fang X, Shi C, Ai J. 2013. MiR-106a is an independent prognostic marker in patients with glioblastoma. Neuro Oncol. 15: 707-17.
  17. Wu J, Ji Z, Liu H, Liu Y, Han D, Shi C, Shi C, Wang C, Yang G, Chen X, Shen C, Li H, Bi Y, Zhang D, Zhao S. 2013. Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway. Toxicol Lett. 220: 61-9.
  18. Mikati AG, Tan H, Shenkar R, Li L, Zhang L, Guo X, Larsson HB, Shi C, Liu T, Wang Y, Shah A, Edelman RR, Christoforidis G, Awad I. 2013. Dynamic Permeability and Quantitative Susceptibility: Related Imaging Biomarkers in Cerebral Cavernous Malformations. Stroke. 45: 598-601.
  19. Yang G, Chen X, Li CG, Zhang DM, Zhang WG, Shi C, Zhao SG. 2013. Multiple meningiomas characterized by benign and malignant tumor entities. CNS Neurosci Ther. 19: 984-6.
  20. Yang G, Han D, Chen X, Zhang D, Wang L, Shi C, Zhang W, Li C, Chen X, Liu H, Zhang D, Kang J, Peng F, Liu Z, Qi J, Gao X, Ai J, Shi C, Zhao S. 2014. MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IkBa both in vitro and in vivo. Neuro Oncol. 16: 652-61.
  21. Tan H, Liu T, Wu Y, Thacker J, Shenkar R, Mikati AG, Shi C, Dykstra C, Wang Y, Prasad PV, Edelman RR, Awad IA. 2014. Evaluation of iron content in human cerebral cavernous malformation using quantitative susceptibility mapping. Invest Radiol. 49: 498-504.
  22. McDonald DA, Shi C, Shenkar R, Gallione CJ, Akers AL, Li S, De Castro N, Berg MJ, Corcoran DL, Awad IA, Marchuk DA. Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. Hum Mol Genet. 2014. [Epub ahead of print]
  23. Shi C, Shenkar R, Kinloch A, Henderson SG, Shaaya M, Chong AS, Clark MR, Awad IA. 2014. Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations. J Neuroimmunol. 272: 67-75.
  24. Shenkar R, Shi C, Rebeiz T, Stockton RA, McDonald DA, Mikati AG, Zhang L, Austin C, Akers AL, Gallione CJ, Rorrer A, Gunel M, Min W, Marcondes de Souza J, Lee C, Marchuk DA, Awad IA. Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. Genet Med. 2015;17:188-96. [*co-1st author]
  25. Na M, Liu Y, Shi C, Gao W, Ge H, Wang Y, Wang H, Long Y, Shen H, Shi C, Lin Z. 2014. Prognostic value of CA4/DG volumetry with 3T magnetic resonance imaging on postoperative outcome of epilepsy patients with dentate gyrus pathology. Epilepsy Research. 108: 1315-25.

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