University of Alberta, Canada

Email: tkin@ualberta.ca

Qualifications

2003 Ph.D., Nara Medical University, Japan

1988 M.D., Nara Medical University, Japan

Publications (selected)

1. Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AMJ. Manning Fox JE, MacDonald PE. Distinct and opposing roles for p110α and p110β in the regulation of insulin secretion from rodent and human beta cells. Diabetologia 2013;56:1339-1349.
2. Manning Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AMJ, Korbutt G, MacDonald PE. Functional plasticity of human infant β-cell exocytotic phenotype. Endocrinology 2013;154:1392-1399.
3. Gala-Lopez B, Kin T, O’Gorman D, Pepper AR, Senior P, Humar A, Shapiro AMJ. Microbial contamination of clinical islet transplant preparations is associated with vey low risk of infection. Diabetes Technol Ther 2013;15:323-327.
4. Kin T, Korbutt GS, Shapiro AMJ. Possible link between ectopic pancreas and holoprosencephaly. Islets 2012;4:207-209.
5. Senior P, Kin T, Shapiro AMJ, Koh A. Islet transplantation at the University of Alberta: status update and review of progress over the last decade. Can J Diabetes 2012;36:32-37.
6. McCall M, Maciver AM, Kin T, Emamaullee J, Pawlick R, Edgar R, Shapiro AMJ. The caspase inhibitor IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Transplantation 2012;94:30-35.
7. Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AMJ, Gaisano HY, Lotan I, MacDonald PE. The Kv2.1 channel regulates insulin secretion from rodent and human islets independent of its electrical function. Diabetologia 2012;55:1709-1720.
8. McCall M, Pawlick R, Kin T, Shapiro AM. Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice. Am J Transplant 2012;12:322-329.
9. Westermark GT, Davalli AM, Secchi A, Folli F, Kin T, Toso C, Shapiro AMJ, Korsgren O, Tufveson G, Andersson A, Westermark P. Further evidence for amyloid deposition in clinical pancreatic islet grafts. Transplantation 2012;93:219-223.
10. Kawahara T, Kin T, Shapiro AMJ. A comparison of islet autotransplantation and allotransplantation and factors elevating acute portal pressure in clinical islet transplantation. J Hepatobiliary Pancreat Sci 2012;19:282-288.
11. Merani S, McCall MD, Pawlick RL, Edgar RL, Davis J, Toso C, Emamaullee JA, Kin T, Shapiro AMJ. AEB-071 (sotrastaurin) does not exhibit toxic effects on human islets nor transplantation into immunodeficient mice. Islets 2011;3:338-343.
12. Gala-Lopez BL, Senior PA, Koh A, Kashkoush SM, Kawahara T, Kin T, Humar A, Shapiro AMJ. Late cytomegalovirus transmission and impact of T-depletion in clinical islet transplantation. Am J Transplant 2011;11:2708-2014.
13. Kawahara T, Kin T, Kashkoush S, Bigam DL, Kneteman NM, Koh A, Senior PA, Shapiro AMJ. Portal vein thrombosis is a preventable complication in clinical islet transplantation. Am J Transplant 2011;11:2700-2707.
14. McCall M, Toso C, Emamaullee J, Pawlick R, Edgar R, Davis J, Maciver A, Kin T, Arch R, Shapiro AMJ. The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice. Surgery 2011;150:48-55.
15. O’Gorman D, Kin T, Imes S, Pawlick R, Senior P, Shapiro AMJ. Comparison of human islet isolation outcomes using a new mammalian tissue free enzyme versus Collagenase NB-1. Transplantation 2010;90:255-259.