Dr. William F. Carson

Department of Pathology,

University of Michigan Medical School, USA

Email: wfcarson@umich.edu

Qualifications

2007 Ph.D., Biomedical Science–Immunology, University of Connecticut Health Center, USA

2002 B.S., Molecular and Cell Biology, University of Connecticut, USA

Publications(Selected)

Books

1. Carson IV, W.F., Kunkel, S.L. “Molecular mechanisms underlying severe sepsis: insights from epigenetics,” Annual Update in Intensive Care and Emergency Medicine 2012 (2012) ISBN 978-3-642-25715-5, Springer, Berlin, Germany.
2. Carson IV., W. F., Kunkel, S. L. “Immune cell dysfunction as a consequence of severe sepsis,” Severe Sepsis and Septic Shock, 1st Ed. (2011) ISBN 978-953-307-854-0, InTech, Rijeka, Croatia.

Journals

1. Matakas, J.D., Balan, V., Carson IV, W.F., Gao, D., Brandizzi, F., Kunkel, S.L., Sticklen, M. (2013) Plant-produced recombinant human interleukin-2 and its activity against splenic CD4+ T cells. International Journal of Life Sciences Biotechnology and Pharma Research, 2(2): 192-203.
2. Mukherjee, S., Allen, R.M., Lukacs, N. W., Kunkel, S. L., Carson IV., W. F. (2012) STAT3 mediated IL‐17 production by post‐septic T cells exacerbates viral immunopathology of the lung. Shock Nov; 38(5)515-523.
3. Ito, T., Allen, R. M., Carson IV., W. F., Schaller, M. A., Cavassani, K. A., Hogaboam, C. M., Lukacs, N. W., Matsukawa, A., Kunkel, S. L. (2011) The Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A Virus (H1N1) Infection. PLoS Pathogens Nov; 7(11): e1002341.
4. Carson IV, W. F., Ito, T., Schaller, M., Cavassani, K. A., Chensue, S. W., Kunkel, S. L. (2011) Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation in adoptive transfer models. PLoS ONE 6(5): e20385.
5. Ito, T., Carson IV, W. F., Cavassani, K. A., Connett, J. M., Kunkel, S. L. (2011) CCR6 as a mediator of immunity in the lung and gut. Experimental Cell Research Mar 10; 317(5): 613-619.
6. Carson IV, W. F., Cavassani, K. A., Dou, Y. Kunkel, S. L. (2011) Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 6(3): 8-18.
7. Schaller, M. A., Logue, H., Mukherjee, S., Lindell, D. M., Coelho, A. L., Lincoln, P., Carson IV, W. F., Ito, T., Cavassani, K. A., Chensue, S. W., Hogaboam, C. M., Lukacs, N. W., Kunkel, S. L. (2010) Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1. PLoS One 5(8): e12172.
8. Cavassani, K. A., Carson IV, W. F., Moreira, A. P., Wen, H., Schaller, M. A., Ishii, M., Lindell, D. M., Dou, Y., Lukacs, N. W., Keshamouni, V.G., Hogaboam, C. M., Kunkel, S. L. (2010) The post sepsis-induced expansion and enhanced function of regulatory T cells creates an environment to potentiate tumor growth. Blood 2010 3; 115(22): 4403-4411.
9. Carson IV, W. F., Cavassani, K. A., Ito, T., Schaller, M. A., Ishii, M., Kunkel, S. L. (2010) Impaired CD4+ T cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Euro. J. Immunol. 40(4): 998-1010.
10. Ishii, M., Wen, H., Corsa, C. A. S., Liu, T., Coehlo, A. L., Allen, R. M., Carson IV, W. F., Cavassani, K. A., Li, X., Lukacs, N. W., Hogaboam, C. M., Dou, Y., Kunkel, S. L. (2009) Epigenetic regulation of the alternatively activated macrophage phenotype. Blood 114(15): 3244-3254.
11. Ito, T., Schaller, M., Raymond, T., Joshi, A.D., Coelho, A.L., Frantz F.G., Carson IV, W.F., Hogaboam, C.M., Lukacs, N.W., Standiford, T. J., Phan, S.H., Chensue, S. W., Kunkel, S. L. (2009) Toll-like Receptor 9 Activation is a Key Mechanism for the Maintenance of Chronic Lung Inflammation. Am. J. Respir. Crit. Care Med. 2009 Dec 15; 180(12): 1227-38.
12. Singh, A., Carson IV, W. F., Secor Jr., E. R., Guernsey, L. A., Flavell, R. A., Clark, R. B., Thrall, R. S., Schramm, C. M. (2008) Regulatory role of B cells in a murine model of allergic airway disease. J. Immunol. 180(11): 7318-7326.
13. Singh, A., Thrall, R.S., Guernsey, L.A., Carson IV, W. F., Secor Jr., E. R, Cone, R. E., Rajan, T.V., Schramm, C. M. (2008) Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model. Immunol. Cell Bio. 86(6): 535-538.
14. Carson IV, W. F., Guernsey, L. A., Singh, A., Vella, A. T., Schramm, C. M., Thrall, R. S. (2007) Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model. Int. Arch. Allergy Immunol. 145(3): 231-243.
15. Secor Jr., E. R., Carson IV, W. F., Singh, A., Pensa, M., Guernsey, L. A., Schramm, C. M., and Thrall, R. S. (2007) Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma. Evid. Based Complement. Altern. Med. Online Advanced Access (3-14-2007).
16. Kabbur, P. M., Carson IV., W. F., Guernsey L. A., Secor Jr., E. R., Thrall, E. R., Schramm, C. M. (2006) Interleukin-10 does not mediate inhalational tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cell Immunol. 239(1): 67-74.
17. Secor Jr., E. R., Carson IV., W. F., Cloutier, M. M., Guernsey, L. A., Schramm, C. M., Wu, C. A., Thrall, R. S. (2005) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol. 237(1): 68-75.