Biography

Dr. Parasuraman Jaisankar

Senior Principal Scientist

Dept. of Medicinal Chemistry

CSIR-Indian Institute of Chemical Biology, India


Email: jaisankar@iicb.res.in, drpjaisankar@gmail.com


Research fields:

Drug Design and Synthesis of Lead Compounds

Synthesis of Lead Compounds and Their Analogues Having Various Biological

Activities, with Special Focus on Anticancer and Anti-Asthmatic, Anti-Microbial, Anti-Leishmanial and Anti-Inflammatory Compounds.

Development of Synthetic Strategy for the Generation of Structurally Unique Bioactive Molecules Especially Nitrogen Heterocycles.

Identification and Structure Elucidation of Antibiotics Isolated From Marine Action-Bacterium Under Drugs from Sea Project. Search for Safe Drugs from Herbal Sources.

Development of Chiral Ligands and Their Transition Metal Complexes for Asymmetric Organic Transformations.


Qualifications

1995 Ph.D., Synthetic Organic Chemistry., Jadavpur University, India

1989 M.Sc., Org. Chem., Presidency College, Chennai (Madras University), India

1987 B.Sc., Chemistry, A. A. Govt. Arts College, (Madras University), India


Publications (Selected)

  1. Tapas Kr. Kundu, Parasuraman Jaisankar, Siddhartha Roy. “International Symposium on Challenges in Chemical Biology: Toward the Formation of Chemical Biology Society of India,” ACS Chem. Biol. 8 (4), 658-661, 2013.
  2. Bapi Gorain, Hira Choudhury, Easha Biswas, Anwesha Barik, Parasuraman Jaisankar, Tapan Kumar Pal. “A novel approach for nanoemulsion components screening and nanoemulsion assay of olmesartan medoxomil through a developed and validated HPLC method,” RSC Advances, 3, 10887-10893 2013.
  3. Anirban Basu, Parasuraman Jaisankar, Gopinatha Suresh Kumar. “Photophysical and calorimetric studies on the binding of 9-O-substituted analogs of the plant alkaloid berberine to double stranded poly(A),” Journal of Photochemistry and Photobiology B: Biology, 3, 105-114, 2013.
  4. Arijit Bhowmik, Nilanjana Das, Uttam Pal, Madhumita Mandal, Seemana Bhattacharya, Moumita Sarkar, Parasuraman Jaisankar, Nakul C. Maiti, Mrinal K. Ghosh. “2,2’-Diphenyl-3,3’-Diindolylmethane: A Potent Compound Induces Apoptosis in Breast Cancer Cells by Inhibiting EGFR Pathway,” PLoS ONE, 8(3): e59798. doi:10.1371/ journal.pone.0059798. 2013.
  5. Anirban Basu, Parasuraman Jaisankar and Gopinatha Suresh Kumar. “Binding of the 9-O-N-aryl/arylalkyl amino carbonyl methyl berberine analogues to tRNAphe:,” PLoS ONE, 8(3): e58279. doi:10.1371/journal.pone.0058279. 2013.
  6. Prasun K Pradhan, Debkumar Nandi, Soma Das Pradhan, Parasuraman Jaisankar and V. S. Giri. “An Unusual Diastereoselective Pictet-Spengler Reaction: Synthesis of Novel Tetrahydro-β-Carboline Glycosides,” Synlett. , 24(1), 85-89,2013.
  7. Sanjit K. Mahato, Jayaraman Vinayagam, Sumit Dey, Ajay K. Timiri, Sourav Chatterjee and Parasuraman Jaisankar. “InCl3 catalysed one-pot synthesis of substituted pyrroles and 2-pyrones,” Aust. Journal of Chemistry, 66, 241-251, 2013.
  8. Sakshi Balwani, Rituparna Chaudhuri, Debkumar Nandi, Parasuraman Jaisankar, Anurag Agrawal, Balaram Ghosh. “Regulation of NF-κB Activation through a Novel PI-3K-Independent and PKA/Akt-Dependent Pathway in Human Umbilical Vein Endothelial Cells,” PLoS ONE 7(10), e46528. doi:10.1371/journal.pone.0046528, 2012.
  9. Sayan Chowdhury, Tulika Mukherjee, Rupkatha Mukhopadhyay, Budhaditya Mukherjee, Souvik Sengupta, Sharmila Chattopadhyay, Parasuraman Jaisankar, Syamal Roy and Hemanta K. Majumder. “The Lignan Niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice,” EMBO, Mol. Med., 4(10), 1126-43, 2012.
  10. Chiranjit Acharya, Sumit Dey, Parasuraman Jaisankar. “Indium trichloride catalyzed three component one-pot route to 1-hydroxymethyl-3-aminomethyl indoles,” Tetrahedron Lett. 53, 5548-51, 2012.
  11. Madhumita Mandal, Saurav Chatterjee and Parasuraman Jaisankar. “Woollins Reagent: A Chemoselective Reducing agent for 1,4-enediones and 1,4-ynediones to Saturated 1,4-Diones,” Synlett. 23(18), 2615-18, 2012.
  12. Sutapa Roy, Madhumita Mandal, Churala Pal, Prabal Giri, Gopinatha Suresh Kumar, Joydeep Mukherjee, Parasuraman Jaisankar. “Studies on aqueous solubility of 3,3’-diindolylmethane derivatives using cyclodextrin inclusion complexes,” Journal of Molecular Structure, 1036, 1-6, 2012.
  13. Debkumar Nandi, Shila Elizabeth Besra, Joseph Rajan Vedasiromoni, Venkatachalam, Sesha Giri, Prince Rana, Parasuraman Jaisankar. “Anti-leukemic activity of Wattakaka volubilis leaf extract against human myeloid leukemia cell lines,” Journal of Ethnopharmacology, 144(3), 466-473, 2012.
  14. D. Kumar, M. Mandal, R. Roy, P.  Jaisankar, P. Das. “Biological Mechanism of Action of Novel −3−(2,5-diphenylfuran-3-yl)−4-methoxy-1H-indole in Human Leukemic Cell Lines,” European Journal of Cancer, 48 (Supplement 5), Page S219, 2012.
  15. Anirban Basu, Parasuraman Jaisankar, Gopinatha Suresh Kumar. “9-O-N-aryl/arylalkyl amino carbonyl methyl substituted berberine analogues induce self-structure in polyadenylic acid,” RSC Advances, 2, 7714-7723, 2012.
  16. Subhadra Garai, Saraswati Garai, Parasuraman Jaisankar, J. K. Singh, Adirajan Elango. “A comprehensive study on crude methanolic extract of Artemisia pallens (Asteraceae) and its active component as effective corrosion inhibitors of mild steel in acid solution,” Corrosion Science, 60, 193-204, 2012.
  17. Anirban Basu, Parasuraman Jaisankar, G Suresh Kumar. “Synthesis of novel 9-O-N-aryl/arylalkyl amino carbonyl methyl substituted berberine analogs and evaluation of DNA binding aspects,” Bioorganic & Medicinal Chemistry, 20, 2498-2505, 2012.
  18. Tulika Mukherjee, Tapas Sarkar, Piyali Paul, Ajit K. Chakraborty, Parasuraman Jaisankar and Siba Brata Mukhopadhyay. “Putralone, a Novel 10α-Hydroxy-25-nor D: A friedo-oleanane Triterpenoid from Putranjiva roxburghii,” Natural Prod. Commun. 7 (4), 511-513, 2012.
  19. Nabendu Biswas, Sanjit Kumar Mahato, Avik Acharya Chowdhury, Jaydeep Chaudhuri, Anirban Manna, Jayaraman Vinayagam, S Chatterjee, Parasuraman Jaisankar, Santu Bandyopadhyay. “ICB3E induces iNOS expression by JNK and ERK activation for apoptosis of leukemic cells,” Apoptosis, 17 (6), 612-626, 2012.
  20. Jayashree Bagchi Chakraborty, Sanjit Kumar Mahato, Kalpana Joshi, Vaibhav Shinde Srabanti Rakshit, Nabendu Biswas, Indrani Mukherjee Choudhury, Labanya Mandal, Dipyaman Ganguly, Avik Acharya Chowdhury, Jaydeep Chaudhuri, Kausik Paul, Bikas C. Pal, Jayaraman Vinayagam, Churala Pal, Anirban Manna, Parasuraman Jaisankar, Siddhartha Roy, Utpal Chaudhury, Aditya Konar, Santu Bandyopadhyay. “Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells by maitochondrial ROS-dependent JNK and eNOS activation and overrides imatinib resistance,” Cancer Science, 103, 88-99, 2012.


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