Department of Microbiology and Molecular Genetics

Hebrew University, Israel

Professor

Email: spigelman@btinternet.com

Qualifications

2011 Visiting Professor, Department of International Health Royal Free and UCL Medical School

Publications (selected)

1. Greenblatt C and Spigelman M 2003. Associate Editors Emerging pathogens: Archaeology, ecology and evolution of infectious disease: Greenblatt C and Spigelman M (eds) Oxford University Press Oxford.
2. Greenblatt C.L, Spigelman M., Cipollaro M., Nerlich A G., and Witas H W. 2010 Eds Proceedings of the 8th and 9th conferences on ancient DNA and Associated Biomolecules Lodz Poland and Pompeii Italy. Gianni Editore Napoli.
3. HD Donoghue, M. Spigelman, J. Zias, A.M. Gernaey-Child and DE Minnikin. 2004. Demonstration of Mycobacterium tuberculosis complex DNA in calcified pleura from remains 1400 years old. In Horvat Karkur ‘llit Dr Pau Figueras (ed) Ben Gurion University of the Desert Press Beer-Sheva.
4. Mark Spigelman, Shin Dong Hoon and Kahila Bar Gal Gila. The Promise, the Problems, and the Future of DNA analysis in Paleopathology Studies. A Companion to Paleopathology Anne L Gauer Editor Blackwell Companions to Archaeology wiley Blackwell UK.
5. Spigelman, M and Lemma, E. 1993: The use of the polymerase chain reaction to detect Mycobacterium tuberculosis in ancient skeletons. International Journal of Osteoarchaeology; 3; 137-143.
6. Rafi, A., Spigelman, M., Stanford, J., Donoghue, H., Lemma, E. and Zias J. 1994: DNA extraction and amplification using PCR of M leprae from a bone from 600 A.D. International Journal of Osteoarchaeology: 4 183. 1-4.
7. Donoghue HD. Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE. 1998 Mycobacterium tuberculosis complex DNA in calcified pleura from remains 1400 yrs old. Letters of Applied Microbiology. 27(5): 265-9.
8. Ubelaker D H., Jones E B., Donoghue H D. and Spigelman M. 2000 Skeletal and Molecular Evidence for Tuberculosis in a Forensic Case. Anthropologie. XXXVIII/2: 193-200.
9. Rothschild B., Martin L., Lev G., Bercovier H., Greenblatt C. and Donoghue H.D, Khila G., Spigelman M. and Brittain D. 2001. Mycobacterium-tuberculosis-complex DNA from an extinct bison dated 17,000 years before the present. 2001. Clinical Infectious Diseases. 1; 33 3): 305-311.
10. Spigelman M, Matheson, C, Lev, M, Greenblatt C. and Donoghue H D.2003. Confirmation of the presence of Mycobacterium tuberculosis- Complex specific DNA in three Archaeological Specimens. International Journal of Osteoarchaeology 12: 393-401.
11. Donoghue H, H Fletcher, Spigelman M  2003. Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. American Journal of Physical Anthropology. 12: 144-52.
12. Douglas Ubelaker, Mark Spigelman Helen D Donoghue, Helen Fletcher, Carney D Matheson and Erica B. Jones. 2003. Evaluation of Evidence for Tuberculosis. In Human Remains from Voegtly Cemetery, Pittsburg Pennsylvania-Smithsonian Contributions to Anthropology No 46 (Douglas Ubelaker and Erica B. Jones eds). Smithsonian Institution Press Washington D.C.
13. Helen D. Donoghue, Mark Spigelman, Charles L. Greenblatt, Galit Lev-Maor, Gila Kahila Bar-Gal, Carney Matheson, Kim Vernon, Andreas G. Nerlich, and Albert R. Zink Tuberculosis from prehistory to Robert Koch - as revealed by ancient DNA Review. Lancet Infectious Diseases Sept 2004.
14. Emilia Nuorala, Anna Kjellström, Anders Götherström, Helen D. Donoghue, Mark Spigelman, & Kerstin Lidén Detection of MTB DNA in a calcified pleura from Jönköping. Molecular Paleopathology. Archaelogical Research Laboratory Stockholm University, ISBN 91-89338-12-x.
15. Nuorala, E., Ahlström, T., Götherström, A., Donoghue, HD., Spigelman, M. & Lidén, K. Tuberculosis in a Scandinavian Neolithic passage grave. Molecular Paleopathology. Archaelogical Research Laboratory Stockholm University, ISBN 91-89338-12-x.
16. Helen Donoghue, Antonia Marcsik, Carney Matheson, Kim Vernon, Emilia Nuorala, Joseph Molto, Charles Greenblatt and Mark Spigelman, 2005. Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples - a possible explanation for the historical decline of leprosy Proceedings of The Royal Society: Biological Sciences. Proceedings B Volume 272, Number 1561 February 22, 389–394.
17. Mark Spigelman 1 Ildicó Pap2, and Helen D. Donoghue1- Leukemia. A death from childhood cancer and tuberculosis in 18th Century Hungary - what palaeopathology can tell us today. 2006 Apr; 20(4): 740-2.
18. Israel Hershkovitz, Helen D. Donoghue, David E. Minnikin, Gurdyal S. Besra, Oona Lee, Angela M. Gernaey, Ehud Galili, Vered Eshed, Charles L. Greenblatt, Eshetu Lemma, Gila Kahila Bar-Gal, Mark Spigelman. Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean PlosOne Oct 2008.
19. Suheir Ereqat, Gila Kahila Bar-Gal, Abedelmajeed Nasereddin, Sawsan Said, Charles L. Greenblatt Kifaya Azmi, Sharif E. Qaddomi, Mark Spigelman, Asad Ramlawi, Ziad Abdeen Pulmonary tuberculosis in the West Bank, Palestinian Authority: Molecular diagnostic approach. Tropical Medicine & International Health.
20. Suheir Ereqat, Gila Kahila Bar-Gal, Abedelmajeed Nasereddin, Kifaya Azmi,1 Sharif E. Qaddomi, Charles L. Greenblatt, Mark Spigelman, and Ziad Abdeen Rapid. Differentiation of Mycobacterium tuberculosis and M. bovis by High-Resolution Melt Curve Analysis  JOURNAL OF CLINICAL MICROBIOLOGY, Nov. 2010, p. 4269–4272 Vol. 48, No. 11.
21. David E. Minnikin, Gurdyal S. Besra, Oona Y-C. Lee. The interplay of DNA and lipid biomarkers in the detection of tuberculosis and leprosy in mummies and other skeletal remains. Yearbook of Mummy Studies volume 1 edited by Dario Piombino-Mascali, Wilfried Rosendahl & Albert Zink: 2011.

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