Andrew M. Tan

Center for Neuroscience and Regeneration Research

Department of Neurology

Yale University School of Medicine, USA

Email: andrew.tan@yale.edu

Qualifications

2006 Ph.D., Stony Brook University, Neurobiology and Behavior

2001 B.S., University of Rochester,Neuroscience

Publications (Selected)

1. Reilmann, R., Tan, A. M., Rosser, A. E., Chen, K., Anderson, K. E., Kostyk, S. K., ... & Hayden, M. R. (2026). Long-Term Slowing of Progression in Huntington’s Disease with Pridopidine Treatment. medRxiv, 2026-02.
2. Kauer, S. D., Effraim, P. R., Bangalore, L., Waxman, S. G., & Tan, A. M. (2026). Dendritic spine dysgenesis in spinal cord injury: A structural contributor to pain and spasticity. Experimental Neurology, 115679.
3. Fukushi, R., Sasaki, M., Obara, H., Kurihara, K., Hirota, R., Morita, T., Tan, A. M.,... & Honmou, O. (2026). Mesenchymal stem cells reverse disease-specific abnormalities in nociceptive regions of the brain. Brain Communications, 8(1), fcaf494.
4. Emek, N. G., Tan, A. M., Geva, M., Fekete, A., Abate, C., & Hayden, M. R. (2025). Pridopidine, a Potent and Selective Therapeutic Sigma-1 Receptor (S1R) Agonist for Treating Neurodegenerative Diseases. Pharmaceuticals, 18(12), 1900.
5. Geva, M., Goldberg, Y. P., Leitner, M. L., Cruz-Herranz, A., Hand, R., Chen, K., Tan, A. M.,... & Hayden, M. R. (2025). Pridopidine treatment in ALS: subgroup analyses from the HEALEY ALS Platform trial. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 1-13.
6. Reilmann, R., Feigin, A., Rosser, A. E., Kostyk, S. K., Saft, C., Cohen, Y., Tan, A. M.,... & PROOF-HD study investigators. (2025). Pridopidine in early-stage manifest Huntington’s disease: a phase 3 trial. Nature Medicine, 31(11), 3780-3789.
7. Goldberg, Y. P., Navon-Perry, L., Cruz-Herranz, A., Chen, K., Hecker-Barth, G., Spiegel, K., Tan, A. M.,... & Hayden, M. R. (2025). The safety profile of pridopidine, a novel Sigma-1 receptor agonist for the treatment of Huntington’s disease. CNS drugs, 39(5), 485-498.
8. Geva, M., Goldberg, Y. P., Schuring, H., Tan, A. M., Long, J. D., & Hayden, M. R. (2025). Antidopaminergic Medications and Clinical Changes in Measures of Huntington's Disease: A Causal Analysis. Movement Disorders, 40(5), 928-937.
9. Tan, A. M., Geva, M., Goldberg, Y. P., Schuring, H., Sanson, B. J., Rosser, A., ... & Anderson, K. (2025). Antidopaminergic medications in Huntington's disease. Journal of Huntington's Disease, 14(1), 16-29.
10. Kauer, S. D., Benson, C. A., Carrara, J. M., Tarafder, A. A., Ibrahim, Y. H., Estacion, M. A., ... & Tan, A. M. (2024). PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury. The Journal of Physiology, 602(19), 5061-5081.
11. Benson, C. A., King, J. F., Reimer, M. L., Kauer, S. D., Waxman, S. G., & Tan, A. M. (2024). Dendritic spines and pain memory. The Neuroscientist, 30(3), 294-314.
12. Benson, C. A., King, J. F., Kauer, S. D., Waxman, S. G., & Tan, A. M. (2023). Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal of Neurophysiology, 130(5), 1358-1366.
13. Benson, C. A., Olson, K. L., Patwa, S., Reimer, M. L., Bangalore, L., Hill, M., ... & Tan, A. M. (2021). Conditional RAC1 knockout in motor neurons restores H-reflex rate-dependent depression after spinal cord injury. Scientific reports, 11(1), 7838.
14. Reimer, M. L., Bangalore, L., Waxman, S. G., & Tan, A. M. (2021). Core principles for the implementation of the neurodata without borders data standard. Journal of Neuroscience Methods, 348, 108972.
15. Chen, L., Huang, J., Benson, C., Lankford, K. L., Zhao, P., Carrara, J., Tan, A. M.,... & Dib-Hajj, S. D. (2020). Sodium channel Nav1. 6 in sensory neurons contributes to vincristine-induced allodynia. Brain, 143(8), 2421-2436.
16. Chen, L., Huang, J., Zhao, P., Persson, A. K., Dib-Hajj, F. B., Cheng, X., Tan, A. M.,... & Dib-Hajj, S. D. (2018). Conditional knockout of NaV1. 6 in adult mice ameliorates neuropathic pain. Scientific reports, 8(1), 3845.
17. Zhao, P., Hill, M., Liu, S., Chen, L., Bangalore, L., Waxman, S. G., & Tan, A. M. (2016). Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker. Journal of neurophysiology, 115(6), 2893-2910.
18. Tan, A. M. (2015). Dendritic spine dysgenesis: an emerging concept in neuropsychiatric disease. Neuroscience letters, 601, 1-3.
19. Bandaru, S. P., Liu, S., Waxman, S. G., & Tan, A. M. (2015). Dendritic spine dysgenesis contributes to hyperreflexia after spinal cord injury. Journal of neurophysiology, 113(5), 1598-1615.
20. Tan, A. M., Samad, O. A., Dib-Hajj, S. D., & Waxman, S. G. (2015). Virus-mediated knockdown of Nav1. 3 in dorsal root ganglia of STZ-induced diabetic rats alleviates tactile allodynia. Molecular medicine, 21(1), 544-552.

Profile Details

https://medicine.yale.edu/profile/andrew-tan/

https://www.researchgate.net/profile/Andrew-Tan-9

https://scholar.google.com/citations?user=LGem5PoAAAAJ&hl=en

WoS Researcher ID: OFJ-1525-2025